22 Result(s)

Article

Measurement of circulating transcripts and gene cluster analysis predicts and defines therapeutic efficacy of peptide receptor radionuclide therapy (PRRT) in neuroendocrine tumors

Peptide receptor radionuclide therapy (PRRT) is an effective method for treating neuroendocrine tumors (NETs). It is limited, however, in the prediction of individual tumor response and the precise and early i...

L. Bodei, M. Kidd, I. M. Modlin, S. Severi… in European Journal of Nuclear Medicine and M… (2016)

Article

Gene transcript analysis blood values correlate with ⁶⁸Ga-DOTA-somatostatin analog (SSA) PET/CT imaging in neuroendocrine tumors and can define disease status

Precise determination of neuroendocrine tumor (NET) disease status and response to therapy remains a rate-limiting concern for disease management. This reflects limitations in biomarker specificity and resolut...

L. Bodei, M. Kidd, I. M. Modlin, V. Prasad… in European Journal of Nuclear Medicine and M… (2015)

Article

Novel ¹¹¹In-labelled bombesin analogues for molecular imaging of prostate tumours

It has been shown that some primary human tumours and their metastases, including prostate and breast tumours, overexpress gastrin-releasing peptide (GRP) receptors. Bombesin (BN) is a neuropeptide with a high...

M. de Visser, H. F. Bernard, J. L. Erion… in European Journal of Nuclear Medicine and M… (2007)

Article

Comparison of [¹⁷⁷Lu-DOTA⁰,Tyr³]octreotate and [¹⁷⁷Lu-DOTA⁰,Tyr³]octreotide: which peptide is preferable for PRRT?

Patients with somatostatin receptor subtype 2-positive metastasised neuroendocrine tumours can be treated with [¹⁷⁷Lu-DOTA⁰,Tyr³]octreotate. Some use octreotide as the peptide for peptide receptor radionuclide th...

J. P. Esser, E. P. Krenning… in European Journal of Nuclear Medicine and M… (2006)

Article

In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals

In vivo quantification of radiopharmaceuticals has great potential as a tool in develo** new drugs. We investigated the accuracy of in vivo quantification with multi-pinhole single-photon emission computed t...

F. Forrer, R. Valkema, B. Bernard… in European Journal of Nuclear Medicine and M… (2006)

Article

Stabilised ¹¹¹In-labelled DTPA- and DOTA-conjugated neurotensin analogues for imaging and therapy of exocrine pancreatic cancer

Neurotensin (NT) receptors are overexpressed in exocrine pancreatic cancer and Ewing's sarcoma. The potential utility of native NT in cancer diagnosis and therapy is, however, limited by its rapid degradation ...

M. de Visser, P. J. J. M. Janssen… in European Journal of Nuclear Medicine and M… (2003)

Article

Treatment of patients with gastro-entero-pancreatic (GEP) tumours with the novel radiolabelled somatostatin analogue [¹⁷⁷Lu-DOTA⁰,Tyr³]octreotate

Medical treatment and chemotherapy are seldom successful in achieving objective tumour reduction in patients with metastatic neuroendocrine tumours. Treatment with the radiolabelled somatostatin analogue [⁹⁰Y-DOT...

D. J. Kwekkeboom, W. H. Bakker, B. L. Kam… in European Journal of Nuclear Medicine and M… (2003)

Article

Comparison of iodine-123 epidepride and iodine-123 IBZM for dopamine D₂ receptor imaging in clinically non-functioning pituitary macroadenomas and macroprolactinomas

We compared pituitary iodine-123 epide- pride single-photon emission tomography (SPET) and ¹²³I-IBZM SPET for the in vivo imaging of dopamine D₂ receptors in 15 patients with clinically non-functioning pituitary...

W. W. de Herder, A. E. M. Reijs, J. de Swart… in European Journal of Nuclear Medicine (1999)

Chapter

Somatostatin Receptor Imaging in Oncology

In diagnosing or staging cancer, conventional imaging techniques such as X-ray computed tomography (CT) or nuclear magnetic resonance imaging (MRI) often seem adequate in detecting tumors commonly encountered ...

D. J. Kwekkeboom, E. P. Krenning in Nuclear Oncology (1999)

Article

Visualization of the thymus by substance P receptor scintigraphy in man

Substance P, an 11-amino acid neuropeptide, has an important role in modulating pain transmission through neurokinin 1 and 2 receptors. Substance P and other tachykinins may also play a role in the pathogenesi...

P. M. van Hagen, W. A. P. Breeman, J. C. Reubi… in European Journal of Nuclear Medicine (1996)

Article

Somatostatin-receptor scintigraphy in Graves' orbitopathy

P. T. E. Postema, D. J. Kwekkeboom, P. M. van Hagen… in European Journal of Nuclear Medicine (1996)

Article

Vascular risk factors, atherosclerosis, cerebral white matter lesions and cerebral perfusion in a population-based study

We studied risk factors for cerebral vascular disease (blood pressure and hypertension, factor VIIc, factor VIIIc, fibrinogen), indicators of atherosclerosis (intima-media thickness and plaques in the carotid ...

J. J. Claus, M. M. B. Breteler, D. Hasan… in European Journal of Nuclear Medicine (1996)

Article

Assessment of cerebral perfusion with single-photon emission tomography in normal subjects and in patients with Alzheimer's disease: effects of region of interest selection

The shape, size and location of regions of interest (ROls) show considerable variability between single-photon emission tomography (SPET) studies in aging and Alzheimer's disease, but the possible influence on...

J. J. Claus, F. van Harskamp, M. M. B. Breteler… in European Journal of Nuclear Medicine (1994)

Article

Somatostatin analogue scintigraphy in granulomatous diseases

Normal as well as activated lymphocytes and macrophages have previously been shown by radioreceptor analysis to express somatostatin receptors (SS-R). The somatostatin (SS) analogue [¹¹¹In-DTPA-d-Phe¹]octreotide ...

P. M. Vanhagen, E. P. Krenning, J. C. Reubi… in European Journal of Nuclear Medicine (1994)

Article

A new radiolabelled somatostatin analogue [¹¹¹In-DTPA-D-Phe¹]RC-160: preparation, biological activity, receptor scintigraphy in rats and comparison with [¹¹¹In-DTPA-D-Phe¹]octreotide

We have evaluated the potential usefulness of indium-111 labelled [DTPA-D-Phe¹]RC-160, derived from the octapeptide somatostatin analogue RC-160, as a radiopharmaceutical for the in vivo detection of somatostatin...

W. A. P. Breeman, L. J. Hofland, M. van der Pluijm… in European Journal of Nuclear Medicine (1994)

Article

A new radiolabelled somatostatin analogue [¹¹¹In-DTPA-D-Phe¹]RC-160: preparation, biological activity, receptor scintigraphy in rats and comparison with [¹¹¹In-DTPA-D-Phe¹]octreotide

We have evaluated the potential usefulness of indium-111 labelled [DTPA-D-Phe¹]RC-160, derived from the octapeptide somatostatin analogue RC-160, as a radiopharmaceutical for the in vivo detection of somatostatin...

W. A. P. Breeman, L. J. Hofland, M. van der Pluijm… in European Journal of Nuclear Medicine (1994)