40 Result(s)

Article

Measurement of circulating transcripts and gene cluster analysis predicts and defines therapeutic efficacy of peptide receptor radionuclide therapy (PRRT) in neuroendocrine tumors

Peptide receptor radionuclide therapy (PRRT) is an effective method for treating neuroendocrine tumors (NETs). It is limited, however, in the prediction of individual tumor response and the precise and early i...

L. Bodei, M. Kidd, I. M. Modlin, S. Severi… in European Journal of Nuclear Medicine and M… (2016)

Article

Gene transcript analysis blood values correlate with ⁶⁸Ga-DOTA-somatostatin analog (SSA) PET/CT imaging in neuroendocrine tumors and can define disease status

Precise determination of neuroendocrine tumor (NET) disease status and response to therapy remains a rate-limiting concern for disease management. This reflects limitations in biomarker specificity and resolut...

L. Bodei, M. Kidd, I. M. Modlin, V. Prasad… in European Journal of Nuclear Medicine and M… (2015)

Article

Novel ¹¹¹In-labelled bombesin analogues for molecular imaging of prostate tumours

It has been shown that some primary human tumours and their metastases, including prostate and breast tumours, overexpress gastrin-releasing peptide (GRP) receptors. Bombesin (BN) is a neuropeptide with a high...

M. de Visser, H. F. Bernard, J. L. Erion… in European Journal of Nuclear Medicine and M… (2007)

Article

Comparison of [¹⁷⁷Lu-DOTA⁰,Tyr³]octreotate and [¹⁷⁷Lu-DOTA⁰,Tyr³]octreotide: which peptide is preferable for PRRT?

Patients with somatostatin receptor subtype 2-positive metastasised neuroendocrine tumours can be treated with [¹⁷⁷Lu-DOTA⁰,Tyr³]octreotate. Some use octreotide as the peptide for peptide receptor radionuclide th...

J. P. Esser, E. P. Krenning… in European Journal of Nuclear Medicine and M… (2006)

Article

In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals

In vivo quantification of radiopharmaceuticals has great potential as a tool in develo** new drugs. We investigated the accuracy of in vivo quantification with multi-pinhole single-photon emission computed t...

F. Forrer, R. Valkema, B. Bernard… in European Journal of Nuclear Medicine and M… (2006)

Article

Estrogen Receptor α Gene Polymorphisms and Bone Mineral Density in Healthy Children and Young Adults

The accretion of peak bone mass is largely under genetic control, and one of the potential candidate genes is the estrogen receptor α (ERα) gene. The association of ERα gene polymorphisms with bone mineral den...

A. M. Boot, I. M. van der Sluis… in Calcified Tissue International (2004)

Article

Vitamin D Receptor Gene Polymorphism Predicts Height and Bone Size, Rather Than Bone Density in Children and Young Adults

Peak bone mass is considered to be under strong genetic control. We studied the association among anthropometry, bone density and vitamin D receptor (VDR) genotype in an ethnically homogeneous group of 148 Cau...

I. M. van der Sluis, S. M. P. F. de Muinck Keizer-Schrama… in Calcified Tissue International (2003)

Article

Stabilised ¹¹¹In-labelled DTPA- and DOTA-conjugated neurotensin analogues for imaging and therapy of exocrine pancreatic cancer

Neurotensin (NT) receptors are overexpressed in exocrine pancreatic cancer and Ewing's sarcoma. The potential utility of native NT in cancer diagnosis and therapy is, however, limited by its rapid degradation ...

M. de Visser, P. J. J. M. Janssen… in European Journal of Nuclear Medicine and M… (2003)

Article

Treatment of patients with gastro-entero-pancreatic (GEP) tumours with the novel radiolabelled somatostatin analogue [¹⁷⁷Lu-DOTA⁰,Tyr³]octreotate

Medical treatment and chemotherapy are seldom successful in achieving objective tumour reduction in patients with metastatic neuroendocrine tumours. Treatment with the radiolabelled somatostatin analogue [⁹⁰Y-DOT...

D. J. Kwekkeboom, W. H. Bakker, B. L. Kam… in European Journal of Nuclear Medicine and M… (2003)

Article

Collagen Ia1 Polymorphism is Associated with Bone Characteristics in Caucasian Children and Young Adults

A large proportion of the variation in bone mass can be explained by genetic factors. We analyzed the G to T substitution in the Sp1 binding site in the first intron of the collagen type Ia1 (COLIA1) gene in r...

I.M. Sluis, S.M.P.F. Muinck Keizer-Schrama, H.A.P. Pols… in Calcified Tissue International (2002)

Article

Somatostatin receptor scintigraphy in the follow-up of patients with differentiated thyroid cancer

The aim of this study was to compare the results of somatostatin receptor scintigraphy (SRS) and of radioiodine scintigraphy in patients with metastatic differentiated thyroid carcinoma during L-thyroxine supp...

L. M. Haslinghuis, E. P. Krenning… in Journal of Endocrinological Investigation (2001)

Chapter and Conference Paper

The Role of Radioactive Somatostatin and Its Analogues in the Control of Tumor Growth

Peptide receptor scintigraphy with the radioactive somatostatin analogue [¹¹¹In-DTPA-D-Phe¹] octreotide is a sensitive and specific technique to show in vivo the presence and abundance of somatostatin receptors o...

E. P. Krenning, R. Valkema, P. P. M. Kooij, W. A. P. Breeman… in Peptides in Oncology III (2000)

Article

Receptor imaging in the diagnosis and treatment of pituitary tumors

A. Colao, S. Lastoria, G. Lombardi… in Journal of Endocrinological Investigation (1999)

Article

Comparison of iodine-123 epidepride and iodine-123 IBZM for dopamine D₂ receptor imaging in clinically non-functioning pituitary macroadenomas and macroprolactinomas

We compared pituitary iodine-123 epide- pride single-photon emission tomography (SPET) and ¹²³I-IBZM SPET for the in vivo imaging of dopamine D₂ receptors in 15 patients with clinically non-functioning pituitary...

W. W. de Herder, A. E. M. Reijs, J. de Swart… in European Journal of Nuclear Medicine (1999)

Article

Receptor imaging in the diagnosis and treatment of pituitary tumors

D. J. Kwekkeboom, W. W. de Herder… in Journal of Endocrinological Investigation (1999)