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  1. Article

    Open Access

    Gastrin-releasing peptide receptor-based targeting using bombesin analogues is superior to metabolism-based targeting using choline for in vivo imaging of human prostate cancer xenografts

    Prostate cancer (PC) is a major health problem. Overexpression of the gastrin-releasing peptide receptor (GRPR) in PC, but not in the hyperplastic prostate, provides a promising target for staging and monitori...

    Rogier P. J. Schroeder, W. M. van Weerden… in European Journal of Nuclear Medicine and M… (2011)

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  2. No Access

    Chapter and Conference Paper

    The Role of Radioactive Somatostatin and Its Analogues in the Control of Tumor Growth

    Peptide receptor scintigraphy with the radioactive somatostatin analogue [111In-DTPA-D-Phe1] octreotide is a sensitive and specific technique to show in vivo the presence and abundance of somatostatin receptors o...

    E. P. Krenning, R. Valkema, P. P. M. Kooij, W. A. P. Breeman… in Peptides in Oncology III (2000)

  3. No Access

    Article

    Visualization of the thymus by substance P receptor scintigraphy in man

    Substance P, an 11-amino acid neuropeptide, has an important role in modulating pain transmission through neurokinin 1 and 2 receptors. Substance P and other tachykinins may also play a role in the pathogenesi...

    P. M. van Hagen, W. A. P. Breeman, J. C. Reubi… in European Journal of Nuclear Medicine (1996)

  4. No Access

    Article

    A new radiolabelled somatostatin analogue [111In-DTPA-D-Phe1]RC-160: preparation, biological activity, receptor scintigraphy in rats and comparison with [111In-DTPA-D-Phe1]octreotide

    We have evaluated the potential usefulness of indium-111 labelled [DTPA-D-Phe1]RC-160, derived from the octapeptide somatostatin analogue RC-160, as a radiopharmaceutical for the in vivo detection of somatostatin...

    W. A. P. Breeman, L. J. Hofland, M. van der Pluijm… in European Journal of Nuclear Medicine (1994)

  5. No Access

    Article

    A new radiolabelled somatostatin analogue [111In-DTPA-D-Phe1]RC-160: preparation, biological activity, receptor scintigraphy in rats and comparison with [111In-DTPA-D-Phe1]octreotide

    We have evaluated the potential usefulness of indium-111 labelled [DTPA-D-Phe1]RC-160, derived from the octapeptide somatostatin analogue RC-160, as a radiopharmaceutical for the in vivo detection of somatostatin...

    W. A. P. Breeman, L. J. Hofland, M. van der Pluijm… in European Journal of Nuclear Medicine (1994)

  6. No Access

    Article

    Radioiodinated somatostatin analogue RC-160: preparation, biological activity, in vivo application in rats and comparison with [123I-Tyr3]octreotide

    We have evaluated the potential usefulness of the radioiodinated octapeptide RC-160, a somatostatin analogue, which might serve as a radiopharmaceutical for the in vivo detection of somatostatin receptor-posit...

    W. A. P. Breeman, L. J. Hofland, W. H. Bakker… in European Journal of Nuclear Medicine (1993)

  7. No Access

    Article

    Somatostatin receptor scintigraphy with [111In-DTPA-d-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients

    Various tumours, classically specified as either neuroendocrine or non-neuroendocrine, contain high numbers of somatostatin receptors, which enable in vivo localization of the primary tumour and its metastases...

    E. P. Krenning, D. J. Kwekkeboom, W. H. Bakker… in European Journal of Nuclear Medicine (1993)

  8. No Access

    Article

    Octreotide scintigraphy localizes somatostatin receptor-positive islet cell carcinomas

    Tyr-3-Octreotide is a synthetic derivative of somatostatin and a somatostatin-receptor analogue. The iodine-123-labelled compound localizes somatostatin-receptor-positive tumours. In this paper two patients ar...

    W. Becker, J. Marienhagen, R. Scheubel… in European Journal of Nuclear Medicine (1991)

  9. No Access

    Article

    Myocardial substrate utilization and hemodynamics following repeated coronary flow reduction in pigs

    The effect of repeated local ischemia and reperfusion on myocardial metabolism and ventricular performance was studied in 12 open-chested pigs fasted overnight. Myocardial ischemia was induced by reduction of ...

    Dr. P. D. Verdouw, W. J. Remme, J. W. de Jong… in Basic Research in Cardiology (1979)