25 Result(s)

Chapter and Conference Paper

A Rare Case of a Large Spinal Meningioma with Mediastinal Extension and Malignant Behavior Classified Histologically as Benign

Aim: To report a rare case of a spinal WHO grade I meningioma extending through intervertebral foramina C7 to D4 with an extensive mediastinal mass and infiltration of the vertebrae, and to discuss the malignant ...

S. Dahdal, R. H. Andres, E. Hewer… in Theranostics, Gallium-68, and Other Radion… (2013)

Article

Targeted alpha-radionuclide therapy of functionally critically located gliomas with ²¹³Bi-DOTA-[Thi⁸,Met(O₂)¹¹]-substance P: a pilot trial

Functionally critically located gliomas represent a challenging subgroup of intrinsic brain neoplasms. Standard therapeutic recommendations often cannot be applied, because radical treatment and preservation o...

D. Cordier, F. Forrer, F. Bruchertseifer… in European Journal of Nuclear Medicine and M… (2010)

Article

Novel ¹¹¹In-labelled bombesin analogues for molecular imaging of prostate tumours

It has been shown that some primary human tumours and their metastases, including prostate and breast tumours, overexpress gastrin-releasing peptide (GRP) receptors. Bombesin (BN) is a neuropeptide with a high...

M. de Visser, H. F. Bernard, J. L. Erion… in European Journal of Nuclear Medicine and M… (2007)

Article

Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals?

Gallium-68 is a metallic positron emitter with a half-life of 68 min that is ideal for the in vivo use of small molecules, such as [⁶⁸Ga-DOTA,Tyr³]octreotide, in the diagnostic imaging of somatostatin receptor-po...

P. Antunes, M. Ginj, H. Zhang, B. Waser… in European Journal of Nuclear Medicine and M… (2007)

Chapter and Conference Paper

Guiding principles applied in the design of GPCR-selective hypothalamic hormone agonists and antagonists

Strategies for the design of peptide agonists and antagonists of gonadotropin releasing hormone (GnRH, one ligand and one receptor) and of receptor-selective agonists and antagonists of somatostatin (SRIF, thr...

J. Rivier, J. Gulyas, J. Erchegyi… in Insights into Receptor Function and New Dr… (2006)

Article

Stabilised ¹¹¹In-labelled DTPA- and DOTA-conjugated neurotensin analogues for imaging and therapy of exocrine pancreatic cancer

Neurotensin (NT) receptors are overexpressed in exocrine pancreatic cancer and Ewing's sarcoma. The potential utility of native NT in cancer diagnosis and therapy is, however, limited by its rapid degradation ...

M. de Visser, P. J. J. M. Janssen… in European Journal of Nuclear Medicine and M… (2003)

Article

Local injection of the ⁹⁰Y-labelled peptidic vector DOTATOC to control gliomas of WHO grades II and III: an extended pilot study

We have previously presented preliminary observations on targeting somatostatin receptor-positive malignant gliomas of all grades by local injection of the radiolabelled peptidic vector ⁹⁰Y-DOTATOC. We now repor...

T. Schumacher, S. Hofer, K. Eichhorn… in European Journal of Nuclear Medicine and M… (2002)

Article

Use of indium-111 pentetreotide somatostatin receptor scintigraphy to detect recurrent thyroid carcinoma in patients without detectable iodine uptake

We conducted a prospective evaluation of somatostatin receptor scintigraphy (SRS) for the diagnosis of recurrent vesicular or papillary thyroid carcinoma in 16 patients with no detectable iodine uptake. SRS w...

E. Garin, A. Devillers, J. Le Cloirec… in European Journal of Nuclear Medicine (1998)

Article

Unsulfated DTPA- and DOTA-CCK analogs as specific high-affinity ligands for CCK-B receptor-expressing human and rat tissues in vitro and in vivo

Receptors for regulatory peptides such as somatostatin or vasoactive intestinal polypeptide are expressed by a number of human neoplasms and can be visualized in vivo with peptide receptor scintigraphy. Recen...

J. C. Reubi, B. Waser, J. C. Schaer, U. Laederach… in European Journal of Nuclear Medicine (1998)

Article

Visualization of the thymus by substance P receptor scintigraphy in man

Substance P, an 11-amino acid neuropeptide, has an important role in modulating pain transmission through neurokinin 1 and 2 receptors. Substance P and other tachykinins may also play a role in the pathogenesi...

P. M. van Hagen, W. A. P. Breeman, J. C. Reubi… in European Journal of Nuclear Medicine (1996)

Article

Noninvasive differentiation of meningiomas from other brain tumours using combined¹¹¹indium-octreotide/^99mtechnetium-DTPA brain scintigraphy

We have studied prospectively 47 patients with CNS tumours including 16 meningiomas and 33 other tumours using combined¹¹¹In-octreotide and^99mTc-DTPA brain scintigraphy.¹¹¹In-octreotide scintigraphy was used to i...

A. Barth, A. R. Haldemann, J. C. Reubi, N. Godoy, H. Rösier… in Acta Neurochirurgica (1996)

Article

Somatostatin analogue scintigraphy in granulomatous diseases

Normal as well as activated lymphocytes and macrophages have previously been shown by radioreceptor analysis to express somatostatin receptors (SS-R). The somatostatin (SS) analogue [¹¹¹In-DTPA-d-Phe¹]octreotide ...

P. M. Vanhagen, E. P. Krenning, J. C. Reubi… in European Journal of Nuclear Medicine (1994)

Article

Somatostatin receptor scintigraphy with [¹¹¹In-DTPA-d-Phe¹]- and [¹²³I-Tyr³]-octreotide: the Rotterdam experience with more than 1000 patients

Various tumours, classically specified as either neuroendocrine or non-neuroendocrine, contain high numbers of somatostatin receptors, which enable in vivo localization of the primary tumour and its metastases...

E. P. Krenning, D. J. Kwekkeboom, W. H. Bakker… in European Journal of Nuclear Medicine (1993)

Article

Use of isotope-labeled somatostatin analogs for visualization of islet cell tumors

The results of visualization of the islet cell tumors of 25 patients after intravenous administration of two isotope-labeled somatostatin analogs (¹²³I-Tyr³-octreotide and¹¹¹In-octreotide) are described. The prim...

C. H. J. van Eyck, H. A. Braining, J. C. Reubi, W. H. Bakker… in World Journal of Surgery (1993)

Chapter

The Role of Somatostatin Receptors in the Diagnosis and Therapy of Cancer

Somatostatin (SS) is a representative member of the family of small regulatory peptides which are often characterised by a wide spectrum of actions in various organs of the human body. One of the most prominen...

J. C. Reubi, E. Krenning, S. W. Lambert in Growth Factors, Peptides and Receptors (1993)

Article

Experimental and clinical studies with somatostatin analogue octreotide in small cell lung cancer

We have detected somatostatin receptors (SSR) by autoradiography in 3/4 established small cell lung cancer (SCLC) cell lines but not in two non-SCLC cell lines. The growth of 1/3 SSR positive SCLC cell lines w...

VM Macaulay, IE Smith, MJ Everard, JD Teale, J-C Reubi… in British Journal of Cancer (1991)

Article

The somatostatin analog Sandostatin (SMS201-995) in treatment of DMBA-induced rat mammary tumors

The effects of treatment with a somatostatin analog (Sandostatin, SMS201-995) were investigated in female rats with dimethylbenzanthracene(DMBA)-induced rat mammary tumors. A 3-week treatment was performed usi...

G. H. Bakker, B. Setyono-Han, J. A. Foekens… in Breast Cancer Research and Treatment (1990)

Article

Absence of somatostatin receptors in psoriatic skin lesions

J. C. Reubi, T. Hunziker in Archives of Dermatological Research (1990)

Chapter and Conference Paper

The Use of Sandostatin® in Insulinomas. The Relation Between In Vivo Responses, the Presence of Somatostatin Receptors and the Development of Tachyphylaxis

Patients with insulin-secreting islet cell tumors are at risk for severe, protracted hypoglycemia. Surgical removal of the tumor is the treatment of choice. During the diagnostic work up, medical treatment for...

S. W. J. Lamberts, J.-C. Reubi in Sandostatin® in the Treatment of Gastroent… (1989)