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Article
Open AccessAdvancements in the fabrication and characterization of actinide targets for superheavy element production
The heaviest elements can exclusively be produced in actinide-target based nuclear fusion reactions with intense heavy-ion beams. Ever more powerful accelerators deliver beams of continuously increasing intens...
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Article
Prognostic factors and follow-up parameters in patients with paroxysmal nocturnal hemoglobinuria (PNH): experience of the Austrian PNH network
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disease characterized by a deregulated complement system, chronic Coombs-negative, intravascular hemolysis, and a variable clinical course with s...
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Article
Open AccessChronic myelomonocytic leukemia patients with RAS pathway mutations show high in vitro myeloid colony formation in the absence of exogenous growth factors
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Article
Selected spectroscopic results on element 115 decay chains
Thirty correlated α-decay chains were observed in an experiment studying the fusion-evaporation reaction 48Ca + 243Am at the GSI Helmholtzzentrum für Schwerionenforschung. The decay characteristics of the majori...
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Article
Preparation of actinide targets for the synthesis of the heaviest elements
The heaviest elements are synthesized in heavy-ion induced hot fusion reactions with various actinide targets. Because the actinide material is often available only in very limited amounts, a deposition method...
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Article
High intensity target wheel at TASCA: target wheel control system and target monitoring
At GSI Darmstadt, the gas-filled recoil separator transactinide separator and chemistry apparatus (TASCA) is in operation for experiments with superheavy elements. It is optimized for hot-fusion reactions with...
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Article
Open AccessA randomised multicentre phase II study with cisplatin/docetaxel vs oxaliplatin/docetaxel as first-line therapy in patients with advanced or metastatic non-small cell lung cancer
This study was designed to compare cisplatin/docetaxel with oxaliplatin/docetaxel in patients with advanced and metastatic non-small lung cancer as a first-line treatment.
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Article
Open AccessFeasibility of perioperative chemotherapy with infusional 5-FU, leucovorin, and oxaliplatin with (FLOT) or without (FLO) docetaxel in elderly patients with locally advanced esophagogastric cancer
The aim of this exploratory subgroup analysis of the fluorouracil, oxaliplatin, docetaxel (FLOT)65+ trial was to determine tolerability and feasibility of perioperative chemotherapy in elderly, potentially ope...
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Article
Open AccessAnthracycline rechallenge using pegylated liposomal doxorubicin in patients with metastatic breast cancer: a pooled analysis using individual data from four prospective trials
The aim of this study was to determine the activity of anthracycline rechallenge using pegylated liposomal doxorubicin (PLD) in patients with metastatic breast cancer (MBC) previously treated with conventional...
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Article
Efficacy and safety of sorafenib in patients with advanced renal cell carcinoma with and without prior cytokine therapy, a subanalysis of TARGET
Before the development of targeted therapies, administration of cytokines (e.g., interleukin-2, interferon-α) was the primary systemic treatment option for advanced renal cell carcinoma. Sorafenib, an oral tar...
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Article
WT1 peptide-specific T cells generated from peripheral blood of healthy donors: possible implications for adoptive immunotherapy after allogeneic stem cell transplantation
The Wilms tumor antigen, WT1, is expressed at high levels in various types of leukemia and solid tumors, including lung, breast, colon cancer and soft tissue sarcomas. The WT1 protein has been found to be high...
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Article
Open AccessValproic acid (VPA) in patients with refractory advanced cancer: a dose escalating phase I clinical trial
Altered histone deacetylase (HDAC) activity has been identified in several types of cancer. This study was designed to determine the safety and maximum tolerated dose (MTD) of valproic acid (VPA) as an HDAC in...
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Article
Open AccessLUD00-014: Phase I Study of recombinant vaccinia-NY-ESO-1 (rV-NY-ESO-1) and recombinant fowlpox-NY-ESO-1 (rF-NY-ESO-1) in patients with NY-ESO-1 or LAGE positive cancers
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Article
Synchronous bilateral endoscopic adrenalectomy: experiences after 18 operations
Background: Patients who undergo unilateral adrenalectomy are known to benefit from the endoscopic procedure. Only a few reports on bilateral endoscopic adrenalectomy exist. The optimal a...
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Article
On the decay properties of 269Hs and indications for the new nuclide 270Hs
In bombardments of 248Cm with 143.7-146.8 MeV 26Mg ions the nuclides 269Hs and presumably 270Hs were produced. After chemical isolation, Hs atoms were identified by observing genetically linked nuclear-decay chai...
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Article
Circulating myeloid colony-forming cells predict survival in myelodysplastic syndromes
The growth characteristics and the prognostic value of cytokine-stimulated myeloid colony formation from peripheral blood mononuclear cells (PBMC) of patients with myelodysplastic syndromes (MDS) are largely u...
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Article
First chemical investigation of hassium (Hs, Z=108)
Recently, the first successful chemical investigation of element 108, hassium (Hs) has been reported [1]. Based on 7 detected atoms, Hs was shown to form a higly volatile oxide, most probably HsO4. Therefore it b...
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Article
Chemical investigation of hassium (element 108)
The periodic table provides a classification of the chemical properties of the elements. But for the heaviest elements, the transactinides, this role of the periodic table reaches its limits because increasing...
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Article
Development of an assembly process and reliability investigations for flip-chip LEDs using the AuSn soldering
A packaging process for flip-chip LEDs (light emitting diodes) is described. The LEDs are picked and placed on a silicon substrate wafer. After reflow the substrates are individualized. AuSn solder is used fo...
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Chapter and Conference Paper
Strategies for the Development of Vaccines to Treat Breast Cancer
Spontaneous regressions of human tumors have been reported in different types of cancer, especially in melanoma and renal cell carcinoma (Gromet et al. 1978; Balch et al. 1992), but also in other types of canc...
