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Article
Open AccessEnergy-optimized approaches: a challenge from the perspectives of pilots and air traffic controllers
Carrying out an approach that is as economical and safe as possible remains a challenge for flight crews, with a multitude of requirements to meet simultaneously. For an aircraft to descend from cruise altitud...
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Article
Open AccessThe Heidelberg cardio-oncology unit (COUNT)—a possible blueprint for improved care of cardio-oncological patients
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Article
Open AccessFAP imaging in rare cancer entities—first clinical experience in a broad spectrum of malignancies
68 Ga-FAPI (fibroblast activation protein inhibitor) is a rapidly evolving and highly promising radiotracer for PET/CT imaging, presenting excellent results in a variety of tumor entities, particularly in epithe....
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Article
Neoadjuvante und adjuvante Therapie beim Pankreaskarzinom
Die Resektion ist die einzige kurative Therapieoption beim Pankreaskarzinom. Adjuvante Chemotherapie kann das krankheitsfreie Überleben und Gesamtüberleben nach Resektion verbessern. Zurzeit werden darüber hin...
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Article
Resistance training as supportive measure in advanced cancer patients undergoing TKI therapy—a controlled feasibility trial
While there is growing evidence for positive effects of progressive resistance training in curatively treated cancer patients, data on advanced cancer patients are scarce. This pilot study aimed at investigati...
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Article
Cooperation of BRAFF595L and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling
Activating BRAF mutations, in particular V600E/K, drive many cancers and are considered mutually exclusive with mutant RAS, whereas inactivating BRAF mutations in the D594F595G596 motif cooperate with RAS via par...
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Article
Salvage-Chirurgie bei Ösophaguskarzinomen
Bei Ösophaguskarzinomen werden nach definitiver Radio(chemo)therapie bei Progression oder Rezidiv oder auf Patientenwunsch immer häufiger Salvage-Ösophagektomien in Tumorboards diskutiert.
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Article
Open AccessPrognostic and predictive value of immunological parameters for chemoradioimmunotherapy in patients with pancreatic adenocarcinoma
Chemoradioimmunotherapy of patients with pancreatic adenocarcinoma from the CapRI trial did not show any benefit of interferon-α in addition to a 5-fluorouracil (5FU)-based treatment. The aim of this study was to...
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Article
Bortezomib improves outcome after SCT in multiple myeloma patients with end-stage renal failure
Patients with multiple myeloma and dialysis-dependent renal failure have dismal outcomes. In this retrospective analysis of a case series, we evaluated 27 consecutive patients, all of whom required haemodialys...
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Article
MicroRNA-mediated multi-tissue detargeting of oncolytic measles virus
Precise oncotropism is required for successful systemic administration of next-generation oncolytic measles viruses (MVs). We have previously established a system for efficient post-entry targeting by insertio...
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Article
Neue Konzepte in der Immuntherapie
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Article
Die Urologie im Konzept der „Comprehensive Cancer Center“
Urologische Malignome stellen ein Viertel der jährlich in Deutschland neu diagnostizierten Krebserkrankungen. Bei zunehmender Inzidenz wird die Behandlung solider und hämatologischer Tumoren gleichzeitig diffe...
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Article
Preoperative therapy of esophagogastric cancer: the problem of nonresponding patients
Preoperative treatment is nowadays standard for locally advanced esophagogastric cancer in Europe. Surprisingly, little attention has been paid to nonresponders so far. The aim of our retrospective exploratory...
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Article
Development of Short Electrical Pulses in a Schottky Line Periodically Loaded with Resonant Tunneling Diodes
The characteristics of a Schottky line periodically loaded with resonant tunneling diodes (RTDs) are discussed for the development of short electrical pulses. RTDs act as electronic switches and exhibit a pron...
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Chapter and Conference Paper
Elastic Registration of Functional MRI Data to Sensorimotor Cortex
Functional MRI (fMRI) studies often critically build on assignments of task related fMRI responses to brain anatomy that presuppose accurate registration of the functional data to anatomical space. Registratio...
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Article
Tumormarker und Biomarker bei Hals-Kopf-Tumoren
Die frühzeitige Diagnose von Rezidiven nach Resektion oder strahlentherapeutischer Behandlung von Plattenepithelkarzinomen der Kopf-Hals-Region bereitet mit bildgebenden Methoden häufig Schwierigkeiten. Der An...
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Article
Generation and electrical contacting of gold quantum dots
We report on first tries in generating a system of 20-nm-wide parallel bars as templates for conductive gold wires, decorated with Au55(PPh3)12Cl6 clusters. The electrical characterization of these quasi one-dime...
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Chapter
An Adaptive and Reactive Management System for Project Coordination
Design processes in chemical engineering are hard to support. In particular, this applies to conceptual design and basic engineering, in which the fundamental decisions concerning the plant design are performe...
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Article
Severe cardiomyopathy in a patient with renal cell carcinoma after treatment with the novel tyrosine kinase inhibitor sunitinib
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Article
Open AccessIntratumoural injection of the toll-like receptor-2/6 agonist ‘macrophage-activating lipopeptide-2’ in patients with pancreatic carcinoma: a phase I/II trial
This phase I/II trial examined safety and efficacy of the toll-like receptor 2/6 agonist MALP-2 in combination with gemcitabine in patients with incompletely resectable pancreas carcinomas. MALP-2 is a toll-li...