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Article
Open AccessUSP40 promotes hepatocellular carcinoma cell proliferation, migration and stemness by deubiquitinating and stabilizing Claudin1
Hepatocellular carcinoma (HCC) is a prevalent malignant tumor that poses a major threat to people’s lives and health. Previous studies have found that multiple deubiquitinating enzymes are involved in the path...
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Chapter and Conference Paper
Thermal Process Analysis in Passive Solar Dormitories in Plateau Areas: Onsite Case Study in Zoige
In order to understand the thermal process of passive solar dormitories in highland areas, this paper establishes a heat transfer model for passive solar student dormitories and analyses the effects of convect...
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Article
Open AccessCarbon dot nanozymes as free radicals scavengers for the management of hepatic ischemia-reperfusion injury by regulating the liver inflammatory network and inhibiting apoptosis
Hepatic ischemia-reperfusion injury (HIRI) is a pathophysiological process during liver transplantation, characterized by insufficient oxygen supply and subsequent restoration of blood flow leading to an overp...
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Article
Open AccessMEX3C as a potential target for hepatocellular carcinoma drug and immunity: combined therapy with Lenvatinib
The immune microenvironment within hepatocellular carcinoma (HCC) is remarkably intricate. Although the combination of an immune checkpoint inhibitor and Lenvatinib can extend the overall survival of HCC patie...
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Article
The regulation of amino acid metabolism in tumor cell death: from the perspective of physiological functions
Amino acids (AAs) are crucial molecules for the synthesis of mammalian proteins as well as a source of energy and redox equilibrium maintenance. The development of tumors also requires AAs as nutrients. Increa...
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Article
Prediction of the long-term flexural behavior of glued laminated bamboo using accelerated creep test
The long-term creep behavior of engineered bamboo composites plays a crucial role in the engineering design of modern bamboo structures. Accelerated test using the stepped isothermal method (SIM) provides a ti...
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Article
Relationship between HuR and tumor drug resistance
Human resistance protein R (HuR), also known as embryonic lethal abnormal visual-like protein (ELAVL1), is an RNA-binding protein widely expressed in vivo that affects the mRNA stability of targeted and is inv...
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Article
BRD9 Inhibition Attenuates Matrix Degradation and Pyroptosis in Nucleus Pulposus by Modulating the NOX1/ROS/NF-κB axis
Intervertebral disc degeneration (IDD) is considered to be the leading cause of low back pain (LBP). The progression of IDD is closely related to the inflammatory microenvironment, which results in extracellul...
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Article
Open AccessClinical characteristics, treatment and prognosis of infants with retinoblastoma: a multicenter, 10-year retrospective analysis
To summarize the characteristics and treatment, and analyze the prognosis of large number of infants with retinoblastoma (RB) in China through a multicenter, 10-year retrospective analysis.
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Article
Synthesis, Crystal Structure, and Antibacterial Activity of Four Novel Oxazolyl Acylhydrazones
Four novel oxazole acylhydrazones, namely 2,4-dihydroxybenzaldehyde-4-oxazole acylhydrazone (I), 2-hydroxy-3-methoxy-4-oxazole acylhydrazone (II), p-dimethylaminobenzaldehyde-4-oxazole acylhydrazone (III), and 2-...
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Article
Open AccessIdentifying the key genes regulating mesenchymal stem cells chondrogenic differentiation: an in vitro study
Mesenchymal stem cells (MSCs) possess the potential to differentiate into chondrocytes, which makes them an ideal source for healing cartilage defects. Here, we seek to identify the essential genes participati...
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Article
Open AccessIrisin enhances chondrogenic differentiation of human mesenchymal stem cells via Rap1/PI3K/AKT axis
Human mesenchymal stem cells (hMSCs) have been proven to have inherent chondrogenic differentiation potential, which appears to be used in cartilage regeneration. Increasing evidence suggests that irisin enhan...
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Article
Open AccessComparison of anterior or posterior approach in surgical treatment of thoracic and lumbar tuberculosis: a retrospective case–control study
With the widespread use of the posterior surgery, more and more surgeons chose posterior surgery to treat thoracic and lumbar tuberculosis. But others still believed that the anterior surgery is more conducive...
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Article
Open AccessSalt-inducible kinases inhibitor HG-9-91-01 targets RIPK3 kinase activity to alleviate necroptosis-mediated inflammatory injury
Receptor-interacting protein kinase 3 (RIPK3) functions as a central regulator of necroptosis, mediating signaling transduction to activate pseudokinase mixed lineage kinase domain-like protein (MLKL) phosphor...
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Article
Open AccessCorrection to: Melatonin prevents bone destruction in mice with retinoic acid-induced osteoporosis
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Article
Open AccessInhibition of nuclear receptor RORα attenuates cartilage damage in osteoarthritis by modulating IL-6/STAT3 pathway
Osteoarthritis (OA) is characterized by cartilage destruction, chronic inflammation, and local pain. Evidence showed that retinoic acid receptor-related orphan receptor-α (RORα) is crucial in cartilage develop...
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Article
Laparoscopic Surgery for Gallbladder Neuroendocrine Carcinoma: a Case Series and Literature Review
Gallbladder neuroendocrine carcinomas (GB-NECs) are a group of rare and heterogeneous neoplasms. There are few reports regarding laparoscopic surgery for GB-NEC cases diagnosed at advanced stage. Three patient...
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Article
Biological features and clinical outcome in infant neuroblastoma: a multicenter experience in Bei**g
Neuroblastoma (NB) is the most common extracranial solid tumor in childhood, with 37% of patients diagnosed during infancy. This study is aimed at evaluating the survival outcome in infants diagnosed with neur...
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Article
Open Access“Without the need for a second visit” initiative improves patient satisfaction with updated services of outpatient clinics in China
To implement the “without the need for a second visit” (WNASV) initiative in our hospital by optimizing the outpatient clinic services via an upgraded information system, in order to increase the quality of ou...
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Article
Open AccessMelatonin promotes bone marrow mesenchymal stem cell osteogenic differentiation and prevents osteoporosis development through modulating circ_0003865 that sponges miR-3653-3p
Little is known about the implications of circRNAs in the effects of melatonin (MEL) on bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation and osteoporosis (OP) progression. The aim of our stu...
