348 Result(s)
within
Dong-** Yun
Biomedicine
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Chapter
Structure-Function Analysis of the HIV Glycoprotein
The envelope glycoprotein complex of replication competent retroviruses is comprised of two polypeptides, an external, glycosylated, hydrophilic polypeptide (SU) and a membrane-spanning protein (TM), that form...
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Article
Open AccessSpecies-specific hemolysis by Vibrio vulnificus cytolysin
Cytolysin has been incriminated as one of the important virulence determinants in V. vulnificus infection that causes septicemia and serious wound infection. Hemolysis by V. vulnificus cytolysin is colloid-osm...
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Article
Mutations in the gene encoding gap junction protein β-3 associated with autosomal dominant hearing impairment
Hearing impairment is the most commonly occurring condition that affects the ability of humans to communicate 1 . More than 50%...
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Article
Open AccessDetection of circulating tumor cells in patients with gastrointestinal tract cancer using RT-PCR and its clinical implications
To investigate the relationship between the presence of circulating tumor cells in different stages of gastrointestinal tract cancer and the subsequent relapse or distant metastasis, circulating levels of CEA ...
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Protocol
Improving the Transcriptional Regulation of Genes Delivered by Adenovirus Vectors
The effectiveness of gene therapy is essentially governed by the ability of the vector to reach the relevant tissue, and once there, to facilitate the expression of appropriate quantities of the gene product. ...
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Article
Changes in expression and immunolocalization of protein associated with toxic bile salts-induced apoptosis in rat hepatocytes
Cholestatic liver injury results from the accumulation of toxic bile salts within the liver. The aim of the present study was to examine the temporal changes in expression and immunolocalization of protein as...
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Article
Pharmacological profiles of an anticholinergic agent, phencynonate hydrochloride, and its optical isomers
To comparatively study the pharmacological profiles of 3-methyl-3-azabicyclo (3,3,1)nonanyl-9-α-yl-α-cyclopentyl-α-phenyl-α-glycolate (phencynonate hydrochloride, CPG), an anticholinergic agent, and its enanti...
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Article
Open AccessAdenovirus-mediated interleukin-12 gene transfer combined with cytosine deaminase followed by 5-fluorocytosine treatment exerts potent antitumor activity in Renca tumor-bearing mice
Therapeutic gene transfer affords a clinically feasible and safe approach to cancer treatment but a more effective modality is needed to improve clinical outcomes. Combined transfer of therapeutic genes with d...
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Chapter and Conference Paper
Osmosensitive Gene Expression of Taurine Transporter and Cyclin C in Embryonic Fibroblast Cells
Hypertonic conditions induce osmoregulatory activity. Molecular mechanism, however, remains to be further elucidated concerning the osmosensitive balancing activity. Using a differential display protocol, the ...
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Article
Open AccessPolymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population
Nasopharyngeal carcinoma (NPC) is one of the most common cancers in southern China. In addition to environmental factors such as Epstein-Barr virus infection and diet, genetic susceptibility has been reported ...
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Article
Antiangiogenic and Apoptotic Properties of a Novel Amphiphilic Folate-Heparin-Lithocholate Derivative Having Cellular Internality for Cancer Therapy
Anitangiogenic and apoptotic properties of a novel chemically modified heparin derivative with low anticoagulant activity were evaluated on the experimental in vitro and in vivo model.
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Article
Effects of long-term, low-dose sex hormone replacement therapy on hippocampus and cognition of postmenopausal women of different apoE genotypes
To study the effects of long-term, low-dose sex hormone replacement therapy (HRT) on the volume and biochemical changes of the hippocampus in postmenopausal women carrying apolipoprotein E (apoE) gene ɛ3 or ɛ4.
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Article
Poster abstracts
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Article
Open AccessMutation analysis of p31comet gene, a negative regulator of Mad2, in human hepatocellular carcinoma
Failure of mitotic checkpoint machinery leads to the chromosomal missegregation and nuclear endoreduplication, thereby driving the emergence of aneuploidy and tetraploidy population. Although abnormal nuclear ...
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Article
Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia
Pro-inflammatory mediators, such as prostaglandin E2 (PGE2) and nitric oxide (NO), and pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, and TNF-α, play pivotal roles in brain injuries. The anti-infla...
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Article
A study on a non-contacting respiration signal monitoring system using Doppler ultrasound
We proposed non-contacting respiration signal monitoring system for sleep apnea syndrome. Experiments were conducted by emitting 40 kHz ultrasound beam, which is set tone burst mode by 1 ms period to a subject...
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Article
Open AccessAssociation of FOXJ1 polymorphisms with systemic lupus erythematosus and rheumatoid arthritis in Korean population
The forkhead-box J1 (FOXJ1) transcription factor could suppress a spontaneous activation of T cells and B cells through an induction of IκBβ that results in repression of NF-κB activity. In Foxj1 deficiency mi...
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Article
Generation of genetic engineering monoclonal antibodies against prion protein
Two strains of Fab monoclonal antibodies (mAbs) against prion protein, designated as IV-66 and IV-78, were selected from the phage display libraries. The gene sequences encoding the light κ chain and heavy Fd ...
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Article
Mitosis orientation in prostate epithelial cells changed by endocrine effect
The aim of the present study was to investigate the effect of androgen and estrogen on mitosis orientation in the prostate epithelial cells of male rats.
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Article
Different expression patterns of CK2 subunits in the brains of experimental animals and patients with transmissible spongiform encephalopathies
To address the possible alteration of casein kinase 2 (CK2) in transmissible spongiform encephalopathies (TSEs), the levels and patterns of CK2 in the brain tissues of hamsters or C57BL mice inoculated intrace...
