-
Article
Open AccessThe role of autophagy in cadmium-induced acute toxicity in glomerular mesangial cells and tracking polyubiquitination of cytoplasmic p53 as a biomarker
Cadmium (Cd) is a highly toxic environmental pollutant that can severely damage the kidneys. Here, we show that Cd-induced apoptosis is promoted by the cytoplasmic polyubiquitination of p53 (polyUb-p53), which...
-
Article
Cytoplasmic sirtuin 6 translocation mediated by p62 polyubiquitination plays a critical role in cadmium-induced kidney toxicity
Sirtuin 6 (Sirt6) is important for maintaining kidney homeostasis and function. Cd exposure increases the risk of develo** kidney diseases. However, the role of Sirt6 in kidney disease mechanisms is unclear....
-
Article
Correction to: Cytoplasmic sirtuin 6 translocation mediated by p62 polyubiquitination plays a critical role in cadmium-induced kidney toxicity
In the original publication the grant number is incorrectly published.
-
Article
Open AccessPolyubiquitination of p62/SQSTM1 is a prerequisite for Fas/CD95 aggregation to promote caspase-dependent apoptosis in cadmium-exposed mouse monocyte RAW264.7 cells
Cadmium(Cd) induces cytotoxicity via autophagy-induced apoptosis in non-activated mouse monocytes; however, the molecular mechanism remains unclear. Here, we show that autophagy induces Fas (CD95/APO-1)-mediat...
-
Article
Open AccessNefopam downregulates autophagy and c-Jun N-terminal kinase activity in the regulation of neuropathic pain development following spinal nerve ligation
Neurodegeneration is associated with changes in basal cellular function due to the dysregulation of autophagy. A recent study introduced the involvement of autophagy during spinal nerve ligation (SNL). Nefopam...
-
Article
Open AccessShikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells
Shikonin, a natural naphthoquinone pigment purified from Lithospermum erythrorhizon, induces necroptosis in various cancer types, but the mechanisms underlying the anticancer activity of shikonin in lung cancer a...
-
Article
Erratum to: Transcriptional regulation, stabilization, and subcellular redistribution of multidrug resistance-associated protein 1 (MRP1) by glycogen synthase kinase 3αβ: novel insights on modes of cadmium-induced cell death stimulated by MRP1
-
Article
Transcriptional regulation, stabilization, and subcellular redistribution of multidrug resistance-associated protein 1 (MRP1) by glycogen synthase kinase 3αβ: novel insights on modes of cadmium-induced cell death stimulated by MRP1
Cadmium (Cd) resistance is associated with the suppression of autophagy in H460 lung cancer cells, which is regulated by phospho(p)serine-glycogen synthase kinase (GSK) 3αβ. However, the involvement of multidr...
-
Article
Cadmium adaptation is regulated by multidrug resistance-associated protein-mediated Akt pathway and metallothionein induction
To elucidate the mechanisms involved in adaptation of lung epithelial cells to cadmium (Cd), we established a cell line that exhibits Cd-resistance (RWI38). RWI38 showed ∼5-fold greater Cd-resistance (MTT assa...
-
Article
Role of the Fas/Fas Ligand death receptor pathway in ginseng saponin metabolite-induced apoptosis in hepg2 cells
This research team found in previous studies, that the ginseng saponin metabolite IH901 induces apoptosis in HepG2 cellsvia a mitochondrial-mediated pathway, which resulted in the activation of caspase-9 and subs...
-
Article
Open AccessExpression of 3b-Hydroxysteroid dehydrogenase and P450 side chain cleavage enzyme in the human uterine endometrium
The enzyme complex 3b-hydroxysteroid dehydrogenase/Δ(5)-Δ(4)-isomerase (3β-HSD) is involved in the biosynthesis of all classes of active steroids. The expression of 3β-HSD in human uterine endometrium during t...
-
Article
Changes in expression and immunolocalization of protein associated with toxic bile salts-induced apoptosis in rat hepatocytes
Cholestatic liver injury results from the accumulation of toxic bile salts within the liver. The aim of the present study was to examine the temporal changes in expression and immunolocalization of protein as...
-
Article
Expression of 3 β-hydroxysteroid/dehydrogenase/Δ5–Δ4/isomerase in the tracheal cartilage of the rat
The enzyme complex 3β-hydroxysteroid dehydrogenase isomerase/Δ5–Δ4 (3β-HSD) is involved in the biosynthesis of all classes of active steroids. In this study, the presence of 3β-HSD was defined in rat tracheal car...
