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Article
Open AccessTumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma
Drug resistance and dose-limiting toxicities are significant barriers for treatment of multiple myeloma (MM). Bone marrow microenvironment (BMME) plays a major role in drug resistance in MM. Drug delivery with...
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Article
Open AccessConcurrent chemo-radiotherapy with proton therapy: reduced toxicity with comparable oncological outcomes vs photon chemo-radiotherapy
Concurrent chemo-radiotherapy is a commonly employed curative treatment approach for locally advanced cancers but is associated with considerable morbidity. Chemo-radiotherapy using proton therapy may be able ...
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Article
Open AccessMolecular and epigenetic regulatory mechanisms of normal stem cell radiosensitivity
Ionizing radiation (IR) therapy is a major cancer treatment modality and an indispensable auxiliary treatment for primary and metastatic cancers, but invariably results in debilitating organ dysfunctions. IR-i...
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Article
Open AccessA convenient, reliable, and fast acoustic pressure field measurement method for magnetic resonance-guided high-intensity focused ultrasound systems with phased array transducers
With the expanding applications of magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU), there is an urgent need for a convenient, reliable, and fast acoustic pressure field measurement method...
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Article
Open AccessTransient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy
Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging. Stem cells exhibit attenuated DNA damage response (DD...
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Chapter
Cytosolic Phospholipase A2 and Autotaxin Inhibitors as Potential Radiosensitizers
Several classes of lipid mediators are initially derived through the action of phospholipase A2 (PLA2) enzymes on phospholipids that release fatty acids and lysophospholipids. Both fatty acids and lysophospholipi...
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Article
Multifunctional FePt Nanoparticles for Radiation-Guided Targeting and Imaging of Cancer
A multifunctional FePt nanoparticle was developed that targets tumor microvasculature via “radiation-guided” peptides, and is detected by both near-infrared (NIR) fluorescence imaging and analytical mass spect...
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Chapter
Molecular Targeted Drug Delivery Radiotherapy
This chapter discusses prosurvival signal transduction pathways, such as PI3K/Akt and MAPK/ERK signaling, induced by ionizing radiation in the tumor microvasculature. Molecular targeting of these radiation-ind...
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Article
A Molecular Imaging Paradigm to Rapidly Profile Response to Angiogenesis-directed Therapy in Small Animals
The development of novel angiogenesis-directed therapeutics is hampered by the lack of non-invasive imaging metrics capable of assessing treatment response. We report the development and validation of a novel ...
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Protocol
Using In Vivo Biopanning for the Development of Radiation-Guided Drug Delivery Systems
This chapter illustrates our protocol for in vivo biopanning using T7 bacteriophage libraries for the purpose of selecting recombinant peptides for the tumor-specific delivery of radiosensitizers to radiation-...
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Article
Noninvasive assessment of cancer response to therapy
Rapid assessment of cancer response to a therapeutic regimen can determine efficacy early in the course of treatment. Although biopsies of cancer can be used to rapidly assess pharmacodynamic response, certain...
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Article
Hedgehog signaling in the murine melanoma microenvironment
The Hedgehog intercellular signaling pathway regulates cell proliferation and differentiation. This pathway has been implicated to play a role in the pathogenesis of cancer and in embryonic blood vessel develo...
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Article
Characterization of Superparamagnetic Nanoparticle Interactions with Extracellular Matrix in an in Vitro System
Controlled dispersion of therapeutic agents within liquid- and gel-filled cavities represents a barrier to treatment of some cancers and other pathological states. Interstitial delivery is compromised by the p...
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Article
Enhanced radiation damage of tumor vasculature by mTOR inhibitors
It is known that radiation activates the phosphoinositol-3 kinase (PI3K)/Akt pathway and that inhibition of PI3K or Akt sensitizes tumor vasculature to radiotherapy. Mammalian target of rapamycin (mTOR) is a d...
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Article
Erratum: XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer
Correction to: Oncogene (2004) 23, 7047–7052. doi: 10.1038/sj.onc.1207929 Since publication of the above manuscript, the authors have identified an error in the ‘Materials and methods’ section of this paper. O...
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Article
XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer
Survivin and XIAP are members of inhibitors of apoptosis (IAPs) family. They are upregulated in various malignancies. Inactivation of these molecules has resulted in chemosensitization. The purpose of this stu...
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Article
The receptor tyrosine kinase inhibitor SU11248 impedes endothelial cell migration, tubule formation, and blood vessel formation in vivo, but has little effect on existing tumor vessels
Antiangiogenic agents produce regression in few tumors in clinical trials, but are effective in preventing recurrences. To determine whether the vascular endothelial growth factor (VEGF) receptor is a molecula...
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Article
The use of antisense oligonucleotides in evaluating survivin as a therapeutic target for radiation sensitization in lung cancer
Elucidating the mechanism of over and under expression of proteins is critical in develo** a better understanding of cancer. Multiple techniques are used to examine differential expression of proteins in cel...
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Article
Imaging mass spectrometry: A new technology for the analysis of protein expression in mammalian tissues
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Article
Modifications of the fiber in adenovirus vectors increase tropism for malignant glioma models
Recombinant adenovirus (Ad) vectors provide a means of local, therapeutic gene delivery to a wide range of neoplasms. Ad-mediated gene therapy trials in malignant glioma models have been limited by the need fo...
