6 Result(s)
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Article
Open AccessControlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production
Intermittent fasting (IF) improves healthy lifespan in animals by a mechanism involving reduced oxidative damage and increased resistance to stress. However, no studies have evaluated the impact of controlled ...
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Article
Open AccessCXCL10+ T cells and NK cells assist in the recruitment and activation of CXCR3+ and CXCL11+ leukocytes during Mycobacteria-enhanced colitis
The role of Mycobacteria in the etiology of Crohn's disease (CD) has been a contentious subject for many years. Recently, our laboratory showed that spontaneous colitis in IL-10-/- mice is driven in part by antig...
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Article
Open AccessThe Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production
We have recently demonstrated that all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid (9-cis RA) promote IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-γ and TNF-α expression by activated human T cells ...
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Article
Open AccessDirect and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes
Vitamin A (VA) deficiency induces a type 1 cytokine response and exogenously provided retinoids can induce a type 2 cytokine response both in vitro and in vivo. The precise mechanism(s) involved in this phenotypi...
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Open AccessAge-associated alterations in CXCL1 chemokine expression by murine B cells
The CXCL1 chemokines, macrophage inflammatory protein-2 (MIP-2) and cytokine-induced neutrophil chemoattractant (KC), have been shown to play a role in a number of pathophysiological disease states including e...
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Article
Open AccessQuantitative differences in lipid raft components between murine CD4+ and CD8+ T cells
Lipid rafts have been shown to play a role in T cell maturation, activation as well as in the formation of immunological synapses in CD4+ helper and CD8+ cytotoxic T cells. However, the differential expression of...
