4 Result(s)
within
Dennie G. A. J. Hebels
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Protocol
A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure
When evaluating compound similarity, addressing multiple sources of information to reach conclusions about common pharmaceutical and/or toxicological mechanisms of action is a crucial strategy. In this chapter...
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Article
Open AccessIdentification of Sex-Specific Transcriptome Responses to Polychlorinated Biphenyls (PCBs)
PCBs are classified as xenoestrogens and carcinogens and their health risks may be sex-specific. To identify potential sex-specific responses to PCB-exposure we established gene expression profiles in a popula...
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Article
Open AccessDynamic adaptation of mesenchymal stem cell physiology upon exposure to surface micropatterns
Human mesenchymal stem (hMSCs) are defined as multi-potent colony-forming cells expressing a specific subset of plasma membrane markers when grown on flat tissue culture polystyrene. However, as soon as hMSCs ...
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Article
Open AccessOn the correlation between material-induced cell shape and phenotypical response of human mesenchymal stem cells
Learning rules by which cell shape impacts cell function would enable control of cell physiology and fate in medical applications, particularly, on the interface of cells and material of the implants. We defin...
