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Article
Open AccessOn the correlation between material-induced cell shape and phenotypical response of human mesenchymal stem cells
Learning rules by which cell shape impacts cell function would enable control of cell physiology and fate in medical applications, particularly, on the interface of cells and material of the implants. We defin...
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Article
Open AccessThe cytokine secretion profile of mesenchymal stromal cells is determined by surface structure of the microenvironment
Mesenchymal stromal cells (MSC) secrete factors that contribute to organ homeostasis and repair in a tissue specific manner. For instance, kidney perivascular mesenchymal stromal cells (kPSCs) can facilitate r...
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Article
Open AccessReduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations
The clusterin (CLU) gene has been identified as an important risk locus for Alzheimer’s disease (AD). Although the actual risk–increasing polymorphisms at this locus remain to be identified, we previously observe...
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Article
Open AccessBoth common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
We have followed-up on the recent genome-wide association (GWA) of the clusterin gene (CLU) with increased risk for Alzheimer disease (AD), by performing an unbiased resequencing of all CLU coding exons and regul...
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Chapter and Conference Paper
XML and CORBA, Synergistic or Competitive?
The extensible Markup Language (XML) is gaining a lot of attention in the Internet world and is adopted by major companies (IBM, Microsoft, Oracle). XML, the open-standards child of SGML, promises to provide p...
