-
Article
Open AccessAlternative exon splicing and differential expression in pancreatic islets reveals candidate genes and pathways implicated in early diabetes development
Type 2 diabetes (T2D) has a strong genetic component. Most of the gene variants driving the pathogenesis of T2D seem to target pancreatic β-cell function. To identify novel gene variants acting at early stage ...
-
Protocol
A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure
When evaluating compound similarity, addressing multiple sources of information to reach conclusions about common pharmaceutical and/or toxicological mechanisms of action is a crucial strategy. In this chapter...
-
Article
Open AccessAlgorithms for differential splicing detection using exon arrays: a comparative assessment
The analysis of differential splicing (DS) is crucial for understanding physiological processes in cells and organs. In particular, aberrant transcripts are known to be involved in various diseases including c...
-
Article
Open AccessMeta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes
Down syndrome (DS; trisomy 21) is the most common genetic cause of mental retardation in the human population and key molecular networks dysregulated in DS are still unknown. Many different experimental techni...
-
Article
Open AccessMeta-Analysis Approach identifies Candidate Genes and associated Molecular Networks for Type-2 Diabetes Mellitus
Multiple functional genomics data for complex human diseases have been published and made available by researchers worldwide. The main goal of these studies is the detailed analysis of a particular aspect of t...
-
Article
Open AccessT2DM-GeneMiner a web resource for meta-analysis and marker identification for type 2 diabetes mellitus
