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  1. Article

    Open Access

    Phenotypic coupling of sleep and starvation resistance evolves in D. melanogaster

    One hypothesis for the function of sleep is that it serves as a mechanism to conserve energy. Recent studies have suggested that increased sleep can be an adaptive mechanism to improve survival under food depr...

    Didem P. Sarikaya, Julie Cridland, Adam Tarakji, Hayley Sheehy in BMC Evolutionary Biology (2020)

  2. Article

    Open Access

    Evidence that natural selection maintains genetic variation for sleep in Drosophila melanogaster

    Drosophila melanogaster often shows correlations between latitude and phenotypic or genetic variation on different continents, which suggests local adaptation with respect to a heterogeneous en...

    Nicolas Svetec, Li Zhao, Perot Saelao, Joanna C Chiu in BMC Evolutionary Biology (2015)

  3. Article

    Open Access

    Genomic analysis of the relationship between gene expression variation and DNA polymorphism in Drosophila simulans

    Understanding how DNA sequence polymorphism relates to variation in gene expression is essential to connecting genotypic differences with phenotypic differences among individuals. Addressing this question requ...

    Mara KN Lawniczak, Alisha K Holloway, David J Begun, Corbin D Jones in Genome Biology (2008)

  4. No Access

    Article

    Codon bias and selection on single genomes

    Arising from: J. B. Plotkin, J. Dushoff & H. B. Fraser Nature 428, 942–945 (2004); see also communication from Nielsen et al.; Chen

    Matthew W. Hahn, Jason G. Mezey, David J. Begun, John H. Gillespie in Nature (2005)

  5. Article

    Genetics of α-amanitin resistance in a natural population of Drosophila melanogaster

    The genetic basis of variation in resistance to natural toxins is of interest for both ecological and evolutionary genetics. The wide variety of larval resources used by Drosophila, both within and between specie...

    David J Begun, Penn Whitley in Heredity (2000)

  6. Article

    Regional variation in fruitflies

    David J. Begun, Charles F. Aquadro in Nature (1994)

  7. No Access

    Chapter

    Selection, Recombination, and DNA Polymorphism in Drosophila

    A goal of molecular population genetics is to provide an historical understanding of evolutionary processes occurring within and between closely related populations. While molecular techniques can, in principl...

    Charles F. Aquadro, David J. Begun, Eric C. Kindahl in Non-Neutral Evolution (1994)

  8. No Access

    Article

    African and North American populations of Drosophila melanogaster are very different at the DNA level

    UNDERSTANDING genetic evolution within species requires an accurate description of variation within and between populations and the ability to distinguish between the potential causes of an observed distributi...

    David J. Begun, Charles F. Aquadro in Nature (1993)

  9. No Access

    Article

    Levels of naturally occurring DNA polymorphism correlate with recombination rates in D. melanogaster

    TWO genomic regions with unusally low recombination rates inDrosophila melanogaster have normal levels of divergence but greatly reduced nucleotide diversity1,2, apparently resulting from the fixation of advantag...

    David J. Begun, Charles F. Aquadro in Nature (1992)