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  1. No Access

    Article

    Codon bias and selection on single genomes

    Arising from: J. B. Plotkin, J. Dushoff & H. B. Fraser Nature 428, 942–945 (2004); see also communication from Nielsen et al.; Chen

    Matthew W. Hahn, Jason G. Mezey, David J. Begun, John H. Gillespie… in Nature (2005)

  2. No Access

    Article

    On Ohta's hypothesis: Most amino acid substitutions are deleterious

    Ohta's hypothesis that most amino acid substitutions are deleterious grew out of a class of population-genetics models called shift models. Recently, shift models have been shown to be biologically unreasonabl...

    John H. Gillespie in Journal of Molecular Evolution (1995)

  3. No Access

    Chapter

    Alternatives to the Neutral Theory

    In the past few years, there has been increasing evidence that much of molecular evolution may not involve neutral alleles. This is almost certainly the case from protein5 and may be true for silent sites in codi...

    John H. Gillespie in Non-Neutral Evolution (1994)

  4. No Access

    Article

    Codon usage divergence of homologous vertebrate genes and codon usage clock

    This paper is concerned with the divergence of synonymous codon usage and its bias in three homologous genes within vertebrate species. Genetic distances among species are described in terms of synonymous codo...

    Manyuan Long, John H. Gillespie in Journal of Molecular Evolution (1991)

  5. No Access

    Article

    The transient properties of balancing selection in large finite populations

    The transient properties of balancing selection in large, but finite, populations are described by means of an asymptotic analysis. Heterotic selection is shown to retard the rate of loss of genetic variation ...

    John H. Gillespie in Journal of Mathematical Biology (1981)

  6. No Access

    Article

    Are evolutionary rates really variable?

    Langley and Fitch (1974, 1976) have shown that the pattern of nucleotide substitutions in proteins is inconsistent with a Poisson process with constant rate. From this they conclude that the rate is temporally...

    John H. Gillespie, Charles H. Langley in Journal of Molecular Evolution (1979)

  7. No Access

    Article

    Sampling theory for alleles in a random environment

    A MAJOR effort in theoretical population genetics has been aimed at develo** statistical tests to distinguish between various explanations of observed patterns of enzyme variation1. Perhaps the most useful resu...

    JOHN H. GILLESPIE in Nature (1977)

  8. No Access

    Chapter and Conference Paper

    A General Model to Account for Enzyme Variation in Natural Populations. IV. The Quantitative Genetics of Viability Mutants

    The current struggle over the interpretation of the observed genetic variation in enzymes in natural populations has generally made little direct use of the wealth of experimental results of the pre-electropho...

    John H. Gillespie in Measuring Selection in Natural Populations (1977)