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Article
Open AccessSingle-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight
Microgravity is associated with immunological dysfunction, though the mechanisms are poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear cells (PBMCs) exposed to short ter...
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Article
Open AccessTelomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing
Telomeres are repetitive nucleoprotein complexes at chromosomal termini essential for maintaining genome stability. Telomeric RNA, or TERRA, is a previously presumed long noncoding RNA of heterogeneous lengths...
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Article
Tuning immunity through tissue mechanotransduction
Immune responses are governed by signals from the tissue microenvironment, and in addition to biochemical signals, mechanical cues and forces arising from the tissue, its extracellular matrix and its constitue...
