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  1. No Access

    Article

    Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis

    Thyroid cancer poses a significant clinical challenge, and our understanding of its pathogenesis is incomplete. To gain insight into the pathogenesis of papillary thyroid carcinoma, transcriptional profiles of...

    Thomas J Giordano, Rork Kuick, Dafydd G Thomas, David E Misek, Michelle Vinco… in Oncogene (2005)

  2. Article

    Open Access

    Distinctive serum protein profiles involving abundant proteins in lung cancer patients based upon antibody microarray analysis

    Cancer serum protein profiling by mass spectrometry has uncovered mass profiles that are potentially diagnostic for several common types of cancer. However, direct mass spectrometric profiling has a limited dy...

    Wei-Min Gao, Rork Kuick, Randal P Orchekowski, David E Misek, Ji Qiu… in BMC Cancer (2005)

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  3. No Access

    Protocol

    Oligonucleotide-Directed Microarray Gene Profiling of Pancreatic Adenocarcinoma

    Successful gene profiling studies involve careful experimental design, use of sensitive and accurate technologies, and statistically valid analysis of experimental results. In this chapter we describe our appr...

    David E. Misek, Rork Kuick, Samir M. Hanash, Craig D. Logsdon in Pancreatic Cancer (2005)

  4. No Access

    Article

    Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas

    The C-CRK gene, cellular homolog of the avian v-crk oncogene, encodes two alternatively spliced adaptor signaling proteins, CRKI (28 kDa) and CRKII (40 kDa). Both CRKI and CRKII have been shown to activate kinase...

    Charles T Miller, Guoan Chen, Tarek G Gharib, Hong Wang, Dafydd G Thomas… in Oncogene (2003)

  5. Article

    Profiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into mice

    Tumor cells cultured in vitro are widely used to investigate the molecular biology of cancers and to evaluate responses to drugs and other agents. The full extent to which gene expression in cancer cells is modul...

    Chad Creighton, Rork Kuick, David E Misek, David S Rickman… in Genome Biology (2003)

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  6. No Access

    Article

    Gene-expression profiles predict survival of patients with lung adenocarcinoma

    Histopathology is insufficient to predict disease progression and clinical outcome in lung adenocarcinoma. Here we show that gene-expression profiles based on microarray analysis can be used to predict patient...

    David G. Beer, Sharon L.R. Kardia, Chiang-Ching Huang… in Nature Medicine (2002)