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Article
Open AccessObesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS
Oncogenic KRAS plays a vital role in controlling tumor metabolism by enhancing aerobic glycolysis. Obesity driven by chronic consumption of high-fat diet (HFD) is a major risk factor for oncogenic KRAS-mediate...
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Article
Open AccessThe immune system in cancer metastasis: friend or foe?
Metastatic disease is the leading cause of death among cancer patients and involves a complex and inefficient process. Every step of the metastatic process can be rate limiting and is influenced by non-maligna...
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Article
Open AccessDuctal activation of oncogenic KRAS alone induces sarcomatoid phenotype
Salivary duct carcinoma (SDC) is an uncommon, but aggressive malignant tumor with a high mortality rate. Herein, we reported the detection of somatic KRAS A146T and Q61H mutations in 2 out of 4 (50%) sarcomatoid ...
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Article
Open AccessTargeting Pancreatic Ductal Adenocarcinoma Acidic Microenvironment
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the USA, accounting for ~40,000 deaths annually. The dismal prognosis for PDAC is largely due to its late diagnosis. Curre...
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Article
The role of protein synthesis and digestive enzymes in acinar cell injury
The acinar cell of the exocrine pancreas produces, stores and secretes enzymes necessary for the digestion and absorption of food. Here, Logsdon and Ji describe two major stressors of the acinar cell, endoplas...
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Article
S100P: a novel therapeutic target for cancer
S100P expression is described in many different cancers, and its expression is associated with drug resistance, metastasis, and poor clinical outcome. S100P is member of the S100 family of small calcium-bindin...
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Reference Work Entry In depth
Molecular Relationships Between Chronic Pancreatitis and Cancer
Chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) have long been known to be related diseases of the exocrine pancreas, however much of the existing literature is focused on identifying the...
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Protocol
Oligonucleotide-Directed Microarray Gene Profiling of Pancreatic Adenocarcinoma
Successful gene profiling studies involve careful experimental design, use of sensitive and accurate technologies, and statistically valid analysis of experimental results. In this chapter we describe our appr...
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Article
Isolation and monolayer culture of guinea pig pancreatic duct epithelial cells
Monolayers of cultured epithelial cells have been prepared from fragments of guinea pig pancreatic excretory ducts isolated by a simple procedure employing collagenase digestion and manual selection, through w...
