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Open AccessCrowd-sourced benchmarking of single-sample tumor subclonal reconstruction
Subclonal reconstruction algorithms use bulk DNA sequencing data to quantify parameters of tumor evolution, allowing an assessment of how cancers initiate, progress and respond to selective pressures. We launc...
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Open AccessIntra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological features
Extension of prostate cancer beyond the primary site by local invasion or nodal metastasis is associated with poor prognosis. Despite significant research on tumour evolution in prostate cancer metastasis, the...
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Open AccessCancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine
Prostate cancer (PrCa) genomic heterogeneity causes resistance to therapies such as androgen deprivation. Such heterogeneity can be deciphered in the context of evolutionary principles, but current clinical tr...
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Open AccessAuthor Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
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Open AccessThe genomic landscape and clonal evolutionary trajectory of classical hairy cell leukemia
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Open AccessAuthor Correction: The evolutionary history of 2,658 cancers
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Open AccessThe architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates
Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development. In the prese...
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Open AccessAfrican-specific molecular taxonomy of prostate cancer
Prostate cancer is characterized by considerable geo-ethnic disparity. African ancestry is a significant risk factor, with mortality rates across sub-Saharan Africa of 2.7-fold higher than global averages1. The c...
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Article
Open AccessClonal diversification and histogenesis of malignant germ cell tumours
Germ cell tumours (GCTs) are a collection of benign and malignant neoplasms derived from primordial germ cells. They are uniquely able to recapitulate embryonic and extraembryonic tissues, which carries progno...
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Open AccessIn utero origin of myelofibrosis presenting in adult monozygotic twins
The latency between acquisition of an initiating somatic driver mutation by a single-cell and clinical presentation with cancer is largely unknown. We describe a remarkable case of monozygotic twins presenting...
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Open AccessAPOBEC3 mutational signatures are associated with extensive and diverse genomic instability across multiple tumour types
The APOBEC3 (apolipoprotein B mRNA editing enzyme catalytic polypeptide 3) family of cytidine deaminases is responsible for two mutational signatures (SBS2 and SBS13) found in cancer genomes. APOBEC3 enzymes a...
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Open AccessWhole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes
Black women across the African diaspora experience more aggressive breast cancer with higher mortality rates than white women of European ancestry. Although inter-ethnic germline variation is known, differenti...
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Open AccessPromises and challenges of adoptive T-cell therapies for solid tumours
Cancer is a leading cause of death worldwide and, despite new targeted therapies and immunotherapies, many patients with advanced-stage- or high-risk cancers still die, owing to metastatic disease. Adoptive T-...
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Open AccessRe-evaluating experimental validation in the Big Data Era: a conceptual argument
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Open AccessMalignant transformation and genetic alterations are uncoupled in early colorectal cancer progression
Colorectal cancer (CRC) development is generally accepted as a sequential process, with genetic mutations determining phenotypic tumor progression. However, matching genetic profiles with histological transiti...
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Open AccessMulti-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases
Metastatic melanoma carries a poor prognosis despite modern systemic therapies. Understanding the evolution of the disease could help inform patient management. Through whole-genome sequencing of 13 melanoma m...
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Author Correction: The evolutionary history of lethal metastatic prostate cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessThe genomic and epigenomic evolutionary history of papillary renal cell carcinomas
Intratumor heterogeneity (ITH) and tumor evolution have been well described for clear cell renal cell carcinomas (ccRCC), but they are less studied for other kidney cancer subtypes. Here we investigate ITH and...
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Open AccessGenetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma
Intratumor heterogeneity (ITH) of genomic alterations may impact prognosis of lung adenocarcinoma (LUAD). Here, we investigate ITH of somatic copy number alterations (SCNAs), DNA methylation, and point mutatio...
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Open AccessDNA copy number motifs are strong and independent predictors of survival in breast cancer
Somatic copy number alterations are a frequent sign of genome instability in cancer. A precise characterization of the genome architecture would reveal underlying instability mechanisms and provide an instrume...