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Article
Open AccessPreviously reported CCDC26 risk variant and novel germline variants in GALNT13, AR, and MYO10 associated with familial glioma in Finland
Predisposing factors underlying familial aggregation of non-syndromic gliomas are still to be uncovered. Whole-exome sequencing was performed in four Finnish families with brain tumors to identify rare predisp...
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Article
Open AccessMitochondrial perturbation in immune cells enhances cell-mediated innate immunity in Drosophila
Mitochondria participate in various cellular processes including energy metabolism, apoptosis, autophagy, production of reactive oxygen species, stress responses, inflammation and immunity. However, the role o...
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Article
Open AccessCancer origin tracing and timing in two high-risk prostate cancers using multisample whole genome analysis: prospects for personalized medicine
Prostate cancer (PrCa) genomic heterogeneity causes resistance to therapies such as androgen deprivation. Such heterogeneity can be deciphered in the context of evolutionary principles, but current clinical tr...
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Article
Deep whole-genome ctDNA chronology of treatment-resistant prostate cancer
Circulating tumour DNA (ctDNA) in blood plasma is an emerging tool for clinical cancer genoty** and longitudinal disease monitoring1. However, owing to past emphasis on targeted and low-resolution profiling app...
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Article
Open AccessBacterial avidins are a widely distributed protein family in Actinobacteria, Proteobacteria and Bacteroidetes
Avidins are biotin-binding proteins commonly found in the vertebrate eggs. In addition to streptavidin from Streptomyces avidinii, a growing number of avidins have been characterized from divergent bacterial spec...
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Article
Open AccessCo-occurrence of four nucleotide changes associated with an adult mitochondrial ataxia phenotype
Mitochondrial DNA maintenance disorders are an important cause of hereditary ataxia syndrome, and the majority are associated with mutations in the gene encoding the catalytic subunit of the mitochondrial DNA ...
