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Article
Open AccessUnconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity
Cancer remains one of the leading causes of mortality worldwide, leading to increased interest in utilizing immunotherapy strategies for better cancer treatments. In the past decade, CD103+ T cells have been asso...
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Article
Open AccessIntra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological features
Extension of prostate cancer beyond the primary site by local invasion or nodal metastasis is associated with poor prognosis. Despite significant research on tumour evolution in prostate cancer metastasis, the...
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Article
Open AccessTOPK modulates tumour-specific radiosensitivity and correlates with recurrence after prostate radiotherapy
Tumour-specific radiosensitising treatments may enhance the efficacy of radiotherapy without exacerbating side effects. In this study we determined the radiation response following depletion or inhibition of T...
