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Article
Open AccessPrevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators
The Fox gene family comprises a large and functionally diverse group of forkhead-related transcriptional regulators, many of which are essential for metazoan embryogenesis and physiology. Defining conserved funct...
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Chapter
Transcriptional Repression in Spemann’s Organizer and the Formation of Dorsal Mesoderm
The early events of vertebrate embryogenesis establish the three germ layers, endoderm, mesoderm and neuroectoderm, and interactions between these lineages, both before and during gastrulation, determine the b...
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Protocol
Mesoderm Induction in Xenopus
Vertebrate mesoderm forms a diversity of tissues, including notochord, somitic muscle, pronephros, mesenchyme, and blood. In the amphibian Xenopus laevis, mesoderm arises in the equatorial region (marginal zone) ...
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Chapter
Regulation of Cell Fate by Processed Vg1 Protein
Mesoderm induction during Xenopus development has been extensively studied, and two members of the transforming growth factor-β family, activin βB and Vg1, have emerged as strong candidates for the natural induce...