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Article
Open AccessSCD – Stem Cell Differentiation Toward Osteoblast Onboard the International Space Station
Microgravity produces a variety of physical, chemical, and biological cues leading to an intricate and largely unresolved network of mechanosensitive molecules, transduction pathways, oxidative stress-related ...
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Article
Open AccessONS: an ontology for a standardized description of interventions and observational studies in nutrition
The multidisciplinary nature of nutrition research is one of its main strengths. At the same time, however, it presents a major obstacle to integrate data analysis, especially for the terminological and semant...
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Article
Open AccessDeciphering the mechanism of action of 089, a compound impairing the fungal cell cycle
Fungal infections represent an increasingly relevant clinical problem, primarily because of the increased survival of severely immune-compromised patients. Despite the availability of active and selective drug...
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Article
Open AccessCharacterization of cervico-vaginal microbiota in women develo** persistent high-risk Human Papillomavirus infection
Changes in cervico-vaginal microbiota with Lactobacillus depletion and increased microbial diversity facilitate human papillomavirus (HPV) infection and might be involved in viral persistence and cancer developme...
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Article
Open AccessPlant microRNAs as novel immunomodulatory agents
An increasing body of literature is addressing the immuno-modulating functions of miRNAs which include paracrine signaling via exosome-mediated intercellular miRNA. In view of the recent evidence of intake and...
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Article
BIOKIS: A Model Payload for Multidisciplinary Experiments in Microgravity
In this paper we report about the BIOKIS payload: a multidisciplinary set of experiments and measurements in the fields of Biology (4) and Dosimetry (3) performed in microgravity. BIOKIS took advantage of the ...
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Article
Open AccessThe Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research
Micronutrients influence multiple metabolic pathways including oxidative and inflammatory processes. Optimum micronutrient supply is important for the maintenance of homeostasis in metabolism and, ultimately, ...
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Article
Open AccessDC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells
The advent of Systems Biology has been accompanied by the blooming of pathway databases. Currently pathways are defined generically with respect to the organ or cell type where a reaction takes place. The cell...
