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Article
Open AccessSCD – Stem Cell Differentiation Toward Osteoblast Onboard the International Space Station
Microgravity produces a variety of physical, chemical, and biological cues leading to an intricate and largely unresolved network of mechanosensitive molecules, transduction pathways, oxidative stress-related ...
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Article
Open AccessEffects of microgravity simulation on zebrafish transcriptomes and bone physiology—exposure starting at 5 days post fertilization
Physiological modifications in near weightlessness, as experienced by astronauts during space flight, have been the subject of numerous studies. Various animal models have been used on space missions or in mic...
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Article
Open AccessThe SCD – Stem Cell Differentiation ESA Project: Preparatory Work for the Spaceflight Mission
Due to spaceflight, astronauts experience serious, weightlessness-induced bone loss because of an unbalanced process of bone remodeling that involves bone marrow mesenchymal stem cells (BMSCs), as well as oste...
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Article
Influence of Oxygen in the Cultivation of Human Mesenchymal Stem Cells in Simulated Microgravity: An Explorative Study
Previous studies indicated that human Adipose Tissue-derived Mesenchymal Stem Cells (AT-MSCs) cultured in simulated microgravity (sim-μg) in standard laboratory incubators alter their proliferation and differe...
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Chapter
Areas of Research
This chapter introduces the main topics of research that have benefited so far from the space environment (reduced gravity, ambient radiation, vacuum, etc.), and provides an outlook for future research develop...
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Article
From hypergravity to microgravity: Choosing the suitable simulator
Cardiovascular system functions are impaired in altered gravity conditions. In particular endothelial cells play a major role being responsible for the integrity of the vascular wall. Due to obvious difficulti...
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Chapter
Cardioprotection by Ischemic Preconditioning
Murry et al. reduced infarct size in dogs through repetitive brief occlusions, preceding prolonged ischemia, and coined this phenomenon “ischemic preconditioning.”13 ATP breakdown was attenuated during the prolon...
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Article
Controversies in preconditioning
Preconditioning is an effective means of protecting the heart against prolonged ischemia by pretreating it with a minor insult, and the present paper reviews various controversies in this highly active field o...
