![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Response of Linear, Branched or Crosslinked Polyethylene Structures on the Attack of Oxygen Plasma
Linear, branched and crosslinked polyethylenes (PE) were exposed to the low-pressure oxygen plasma for 2–120 s. In the following the samples were washed with solvents to remove low-molecular weight oxidized ma...
-
Article
High-dose chemotherapy with autologous stem cell rescue in children with retinoblastoma
Children with metastatic retinoblastoma are considered to have a poor prognosis after conventional chemotherapy. We used high-dose chemotherapy (HDC) with peripheral hematopoietic stem cell transplantation in ...
-
Article
TG-MS and TG-FTIR applied for an unambiguous thermal analysis of intumescent coatings
Thermogravimetry (TG), thermogravimetry coupled with mass spectroscopy (TG-MS) and thermogravimetry coupled with Fourier transform infrared spectroscopy (TG-FTIR) were used to characterise the thermo-oxidative...
-
Article
Determination of Halogenated Hydrocarbons in Insulating Polymeric Foams
A simultaneous thermal analysis/mass spectroscopy system was used for the determination of halogenated hydrocarbons in polymeric foam insulation materials. The investigation of ten different polymeric foams sh...
-
Article
The thermal behavior of triethylenediammonium salts
(trienH2)[CoCl4], which contains tetrahedral chlorocobaltate(II) anions, decomposes under argon in two stages via a stepwise deprotonation of the cation. The decomposition starts at 310°C with the liberation of H...
-
Chapter
Peculiarities and Possible Mode of Actions of Thalidomide
Thalidomide is a Janus-faced substance par excellence. It may be argued that a two-sided behavior is typical for all substances, exhibiting beneficial and adverse effects simultaneously or at least at differen...
-
Article
Four generation reproductive toxicity study with 2,3,7,8-tetrachlorodibenzo-P-dioxin (TCDD) in rats
A multigeneration study on the reproductive toxicity of TCDD in rats was conducted. In this paper, the results of extensive pharmacokinetic evaluations are presented. The time course of tissue concentrations w...
-
Chapter and Conference Paper
Probleme mit Fremdstoffen — insbesondere Dioxinen — in der Frauenmilch
Man, being situated at the end of the food chain, has been exposed to a variety of persistent and very lipophilic environmental substances that accumulate in the adipose tissue of the general population world-...
-
Article
Ofloxacin in juvenile non-human primates and rats. Arthropathia and drug plasma concentrations
Arthropathia in juvenile animals is the most important toxic effect induced by quinolones. We conducted pharmacokinetic and morphological studies with ofloxacin on non-human primates (Callithrix jacchus, Marmoset...
-
Article
Activity of aldrinepoxidase, 7-ethoxycoumarin-O-deethylase and 7-ethoxyresorufin-O-deethylase during the development of chick embryos in ovo
Since the chick embryoin ovo is susceptible to the action of some agents needing metabolic activation we studied the development of the activity of cytochrome P450-dependent monooxygenases in embryo/fetal tissue....
-
Chapter and Conference Paper
Automatic detection of Korotkoff sounds, markers for systolic and diastolic blood pressure in automated instruments
Since 1905, when Korotkoff developed the auscultatory method to measure blood pressure, this technique has evolved to become the standard method for non-invasive blood pressure determination. When in the late ...
-
Chapter and Conference Paper
Studies on the Reproductive Toxicity of Diprafenone in Rats
The studies with diprafenone were aimed at evaluating possible adverse effects on reproduction, including male and female fertility, as well as embryo/fetal and perinatal/postnatal development in rats. The stu...
-
Article
Influence of 13-cis and all- trans retinoic acid on rat embryonic development in vitro: correlation with isomerisation and drug transfer to the embryo
In vitro experiments using whole rat embryo cultures show that all -trans retinoic acid (all- trans RA) administered at low concentrations (30 ng/ml culture medium) is 10 times more active than 13-cis retinoic ac...
-
Article
220. Behandlungstaktik bei offenen Luxationen und Frakturen des Fußes
We observed 19 open injuries among 512 fractures and dislocations of the foot within 7 years, from 1978 to 1985. Definitive primary treatment of the injury should be carried out as soon as possible. Lag-screw ...
-
Chapter
Differential Study of 252Cf(sf) Neutron Emission
The double-differential probability N(E, θ) of 252Cf(sf) neutron emission (E - ls neutron energy,
-
Chapter and Conference Paper
Welche Medikamente in der Schwangerschaft?
Gelegentlich werden Arzneimittel während der Schwangerschaft verordnet, um therapeutische Wirkungen auf den Keim auszuüben. So wird z.B. mit Glukokortikoiden versucht, die Lungenentwicklung in utero zu fördern...
-
Article
LD50 versus acute toxicity
Based on today's extensive experience on acute toxicity testing of chemical substances, and on the outcome of specific studies (Schütz and Fuchs 1982; Müller and Kley 1982; Lorke in preparation; Günzel et al. ...
-
Article
Embryotoxicity induced by alkylating agents: 1. Ethylmethanesulfonate as a teratogen in mice
The directly acting monofunctional alkylating agent ethylmethanesulfonate is a potent teratogen in NMRI mice. Inspection of skeletal abnormalities revealed a clear-cut phase specificity of the teratogenic outc...
-
Chapter and Conference Paper
Testing for Embryotoxicity
No animal species exists with which the situation in man can be completely mimicked. This also holds true for non-human primates. With animal experiments only certain aspects of the whole complex situation can...
-
Chapter and Conference Paper
Drug-Induced Damage to the Embryo or Fetus
The exclusion of possible toxicologic hazards is still encumbered with the evaluation of three problems involving major difficulties: carcinogenicity, “teratogenicity,” and mutagenicity. In this paper we will ...