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Article
RET-mediated autophagy suppression as targetable co-dependence in acute myeloid leukemia
Many cases of AML are associated with mutational activation of receptor tyrosine kinases (RTKs) such as FLT3. However, RTK inhibitors have limited clinical efficacy as single agents, indicating that AML is dri...
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Article
JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia
The transcription factor JUN is frequently overexpressed in multiple genetic subtypes of acute myeloid leukemia (AML); however, the functional role of JUN in AML is not well defined. Here we report that short ...
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Article
Open AccessGene expression and proliferation biomarkers for antidepressant treatment resistance
The neurotrophic hypothesis of depression suggests an association between effects on neuroplasticity and clinical response to antidepressant drug therapy. We studied individual variability in antidepressant dr...
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Article
Open AccessProliferation rates and gene expression profiles in human lymphoblastoid cell lines from patients with depression characterized in response to antidepressant drug therapy
The current therapy success of depressive disorders remains in need of improvement due to low response rates and a delay in symptomatic improvement. Reliable functional biomarkers would be necessary to predict...
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Article
Cooperation of BRAFF595L and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling
Activating BRAF mutations, in particular V600E/K, drive many cancers and are considered mutually exclusive with mutant RAS, whereas inactivating BRAF mutations in the D594F595G596 motif cooperate with RAS via par...
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Article
Personalisierte Arzneitherapie auf genetischer Grundlage
Die Pharmakogenetik ist ein wichtiger Baustein in der Individualisierung von Therapien. Eine pharmakogenetische Diagnostik findet jedoch bislang noch wenig Anwendung in der medizinischen Praxis. Eine konsequen...
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Article
Erratum to: Neutron particle-hole structure of states in 208Pb determined from the proton decay of the d5/2 isobaric analog resonance in 209Bi
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Article
Neutron particle-hole structure of states in 208Pb determined from the proton decay of the d5/2 isobaric analog resonance in 209Bi
Proton scattering on 208Pb via isobaric analog resonances (IARs) in 209Bi generates neutron particle-hole configurations in excited states of 208Pb . The spin and parity of the neutron particle correspond to the ...
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Article
Observation of five high-spin members of the g9/2f7/2 multiplet in 208Pb
In the doubly magic nucleus 208Pb , five states are observed at 5648, 5658, 5686, 5694, 5836keV by 208Pb (p, p′) via isobaric analog resonances in 209Bi . The 5686, 5694, 5836 states with spins 6-, 7-, 8- are sho...
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Article
High-resolution study of 0+ and 2+ excitations in 168Er with the (p, t) reaction
Excited states in the deformed nucleus 168Er have been studied with high energy resolution in the (p, t) reaction, with the Munich Q3D spectrograph. A large number of excited 0+ states (25) and 2+ states (64) hav...
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Article
Alternative interpretation of E0 strengths in transitional regions
A strong rise of E0 transition strengths between the first excited 0+ state and the ground state is predicted in shape transitional regions within the Interacting Boson Model (IBM). This rise matches well existin...
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Article
A measure for triaxiality from K (shape) invariants
We show that the cubic shape invariant K3, which provides a measure for triaxiality for β-rigid nuclei, can be obtained from a small number of observables. This affords approximations which have been tested to ho...
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Chapter and Conference Paper
A measure for triaxiality from K (shape) invariants
We show that the cubic shape invariant K 3, which provides a measure for triaxiality for β-rigid nuclei, can be obtained from a small number of observables. This affords approximations whi...
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Chapter and Conference Paper
Alternative interpretation of E0 strengths in transitional regions
A strong rise of E0 transition strengths between the first excited 0+ state and the ground state is predicted in shape transitional regions within the Interacting Boson Model (IBM). This rise matches well existin...
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Chapter and Conference Paper
Molecular Cytogenetic Characterization of a Critical Region in Bands 7q35-q36 Commonly Deleted in Malignant Myeloid Disorders
Cytogenetic studies have shown loss of chromosome 7 (−7) or deletions of the long arm (7q-) in various tumor types. These findings suggest that chromosome 7 harbours tumor suppressor genes which play a role in...
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Chapter and Conference Paper
Molecular Screening of Acute Myeloid Leukemia Using Interphase Cytogenetics
The objective of this study was to design DNA probe sets that enable the detection of chromosome abnormalities in AML by interphase cytogenetics using fluorescence in situ hybridization (FISH), and to compare ...
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Chapter and Conference Paper
Fluorescence In Situ Hybridization for the Diagnosis and Follow-up of BCR-ABL Positive ALL
The BCR-ABL fusion, which is the molecular counterpart of the t(9;22), is the most common genetic abnormality in adult acute lymphoblastic leukemia (ALL) [1]. Due to its important diagnostic and prognostic sig...
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Chapter and Conference Paper
Designing Probe Sets for the Detection of Chromosome Abnormalities in Acute Myeloid Leukemia Using Fluorescence In Situ Hybridization
In recent years, the karyotype as a prognostic factor in acute myeloid leukemia (AML) has gained considerable interest. Clonal chromosome aberrations are identified in 50–60% of patients with AML (for review s...
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Chapter and Conference Paper
Wahrscheinlichkeit, Statistik und Recht
Der Autor beginnt mit dem Aphorismus “iudex non calculat” (der Richter rechnet nicht), um dann an Hand von Beispielen aus dem Zivil- und Strafrecht sowie dem Öffentlichen Recht und dem Prozeßrecht zu zeigen, d...
