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  1. No Access

    Article

    Addition of interleukin-12 to GA733 tumor protein vaccine leads to development of tumor protective immunity despite surgical stress

    Background: We have previously shown that preoperative vaccination with the GA733 protein does not inhibit tumor growth in mice undergoing open surgery or carbon dioxide insufflation. In ...

    I. Kirman, N. Poltoratskaia, D. Herlyn… in Surgical Endoscopy And Other Interventiona… (2003)

  2. No Access

    Chapter and Conference Paper

    Immunmonitoring unter adjuvanter aktiv-spezifischer Immuntherapie beim Pankreas- und kolorektalen Karzinom

    Frühere Immuntherapiestudien wurden meistens ohne begleitendes Immunmonitoring durchgeführt, so daß der Therapieeffekt nur anhand klinischer und bildgebender Diagnostik beurteilt werden konnte. Über die erzeug...

    Dr. biol. hum. Heidi Braumüller, C. Leeser… in Chirurgisches Forum ’99 für experimentelle… (1999)

  3. No Access

    Chapter and Conference Paper

    Erste erfolgreiche Immunisierung von Pankreas- und kolorektalen Karzinompatienten mit CO17-1A-Vakzin

    Mit dem monoklonalen Antikörper Mab C017-1A (Panorex ®) konnte erstmals in einer randomisierten Studie ein Therapievorteil von 30% in der adjuvanten Behandlung von kolorektalen Karzinomen gezeigt werden [1]. Das ...

    Dr. med. Ludger Staib, H. Braumüller, C. Leeser, H. G. Beger… in Chirurgisches Forum ’98 (1998)

  4. No Access

    Article

    Expression of an antigen homologous to the human CO17-1A/GA733 colon cancer antigen in animal tissues

    The CO17-1A/GA733 antigen is associated with human carcinomas and some normal epithelial tissues. This antigen has shown promise as a target in approaches to passive and active immunotherapy of colorectal canc...

    J Zaloudik, S Basak, M Nesbit, DW Speicher, WH Wunner… in British Journal of Cancer (1997)

  5. Article

    Anti-idiotype cancer vaccines: past and future

     Anti-idiotypic antibodies (Ab2) binding to the antigen-combining site of antitumor antibodies (Ab1) can induce anti-anti-idiotypic antibodies (Ab3) that specifically bind to the tumor antigen recognized by Ab...

    D. Herlyn, Rajasekharan Somasundaram, Wei** Li… in Cancer Immunology, Immunotherapy (1996)

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  6. Article

    Animal models of human-derived cancer vaccines

    Preclinical cancer vaccine studies must address vaccine safety, immunogenicity, and efficacy, as well as mechanism of vaccine action. Animal models of vaccines employing human tumor-associated antigen or epito...

    D. Herlyn, R. Somasundaram, W. Li, L. Jacob in Cell Biophysics (1995)

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  7. No Access

    Article

    Anti-idotype and recombinant antigen in immunotherapy of colorectal cancer

    The CO17-1A/GA733 antigen (Ag), bound by monoclonal antibodies (MAb) CO17-1A and GA733 that define two different epitopes on the Ag, has proven a useful target in passive and active immunotherapy of colorectal...

    D. Herlyn, R. Somasundaram, J. Zaloudik, L. Jacob, D. Harris… in Cell Biophysics (1994)

  8. No Access

    Chapter

    Effector Cells in ADCC with Anti-Breast Cancer Monoclonal Antibodies

    A considerable body of data has been accumulated as evidence for the existence of tumor associated antigens in human mammary tumors (1–5). Introduction of hybridoma technology has resulted in detection and cha...

    Z. Steplewski, M. Blaszczyk, D. Herlyn… in Monoclonal Antibodies and Breast Cancer (1985)

  9. No Access

    Chapter

    Human Antibody Induction to the Idiotypic and Anti-Idiotypic Determinants of a Monoclonal Antibody Against a Gastrointestinal Carcinoma Antigen

    Murine monoclonal antibodies (Mab) generated against human tumor antigens (Koprowski and Steplewski 1982) have renewed scientific and clinical interest in passive immunotherapy of human cancer (Kennett et aL 1980...

    E. DeFreitas, H. Suzuki, D. Herlyn… in Images of Biologically Active Structures i… (1985)