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Article
Open AccessBenchmarking satellite-derived shoreline map** algorithms
Satellite remote sensing is becoming a widely used monitoring technique in coastal sciences. Yet, no benchmarking studies exist that compare the performance of popular satellite-derived shoreline map** algor...
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Article
Open AccessLong-term cancer surveillance: results from the Forteo Patient Registry Surveillance Study
The Forteo Patient Registry estimated the incidence of osteosarcoma in US patients treated with teriparatide and enrolled in the study between 2009 and 2019. No incident cases of osteosarcoma were identified a...
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Article
Open AccessTesting the construct validity of a soccer-specific virtual reality simulator using novice, academy, and professional soccer players
Virtual reality (VR) provides the potential for immersive and engaging training solutions for improving sport performance. However, if VR training is to be adopted and used in an effective and evidence-based f...
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Article
Community composition predicts photogrammetry-based structural complexity on coral reefs
The capacity of coral reefs to provide ecosystem services is directly related to their three-dimensional structural complexity. This parameter is also correlated with total fish biomass, reef resilience to ext...
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Article
Open AccessThe Forteo Patient Registry linkage to multiple state cancer registries: study design and results from the first 8 years
The Forteo Patient Registry (FPR) aims to estimate the incidence of osteosarcoma in US patients treated with teriparatide. Enrollment began in 2009 and will continue through 2019, with linkage planned through ...
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Article
Inflammatory cell ratios predict major septic complications following rectal cancer surgery
The inflammatory response is known to have an important role in tumourigenesis and the response to treatment. Previous studies have demonstrated that inflammatory cell ratios such as the neutrophil-to-lymphocy...
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Article
Ibrutinib modulates the immunosuppressive CLL microenvironment through STAT3-mediated suppression of regulatory B-cell function and inhibition of the PD-1/PD-L1 pathway
Ibrutinib, a covalent inhibitor of Bruton Tyrosine Kinase (BTK), is approved for treatment of patients with relapsed/refractory or treatment-naïve chronic lymphocytic leukemia (CLL). Besides directly inhibitin...
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Chapter and Conference Paper
Compaction Properties of Municipal Solid Waste
Waste compaction decrease insitu waste void, improve landfill stability and extend landfill life. Recently buried waste was excavated from two large pits in Johannesburg Robinson Deep Landfill site. The compa...
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Article
Open AccessHughes Abdominal Repair Trial (HART) – Abdominal wall closure techniques to reduce the incidence of incisional hernias: study protocol for a randomised controlled trial
Incisional hernias are common complications of midline closure following abdominal surgery and cause significant morbidity, impaired quality of life and increased health care costs.
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Chapter
Welding and Weldability of AZ31B by Gas Tungsten Arc and Laser Beam Welding Processes
Welding will play an important role in the fabrication of modular lightweight structures based on magnesium alloy die castings, extrusion profiles and wrought products. Minimisation of rejection rates during f...
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Article
Open AccessIpomoea (Convolvulaceae) in Bolivia
An account of the genus Ipomoea L. in Bolivia is presented. 102 species are recognised in the country and each of these is described. Notes are provided on diagnostic features, distribution, habitat, phenology an...
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Chapter
Adapting Agriculture to Climate Change by Develo** Promising Strategies Using Analogue Locations in Eastern and Southern Africa: A Systematic Approach to Develop Practical Solutions
From 2011 to 2014, the CALESA project was a research-for-development project which coupled integrated climate risk analyses, crop growth simulation modelling and field-based research both on-station and on-the...
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Chapter
Maternal Phenylketonuria: Long-term Outcomes in Offspring and Post-pregnancy Maternal Characteristics
Maternal phenylketonuria (MPKU) is a well-recognized complication of PKU and one of the most potent teratogenic syndromes of pregnancy. Virtually all offspring from untreated pregnancies in women with classic ...
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Article
The neuropathological profile of mild cognitive impairment (MCI): a systematic review
Whether mild cognitive impairment (MCI) has a distinct neuropathological profile that reflects an intermediate state between no cognitive impairment and dementia is not clear. Identifying which biological even...
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Article
Open AccessFirst-in-man phase I trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours
PM00104 binds guanines at DNA minor grooves, impacting DNA replication and transcription. A phase I study was undertaken to investigate safety, dose-limiting toxicities (DLTs), recommended phase II dose (RP2D)...
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Article
Open AccessDocumenting end-of-life care plans on the ICU: using a digital proforma may improve compliance with nationally agreed standards
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Article
Classical and non-classical kinematic fields of two-dimensional penetration tests on granular ground by discrete element method analyses
The penetration test is a widely used in-situ test in geotechnical engineering which mechanism is very important to geomechanics. This paper presents a numerical study on both classic and non-classic kinematic...
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Article
Open AccessThe genome of the simian and human malaria parasite Plasmodium knowlesi
Four distinct Plasmodium species are known to regularly infect humans: Plasmodium falciparum, P. vivax, P. malariae and P. ovale. The genome sequence of P. falciparum, the cause of the most severe type of human m...
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Article
The surgical management of fistula-in-ano in a specialist colorectal unit
Fistula-in-ano can be associated with a number of conditions, including Crohn’s disease. The majority, however, are classified as idiopathic or cryptoglandular. The aim of this study was to review the outcome ...
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Article
Development of a generic activities model of command and control
This paper reports on five different models of command and control. Four different models are reviewed: a process model, a contextual control model, a decision ladder model and a functional model. Further to t...
