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Article
Internal hydraulic jump in the Tsugaru Strait
Sea straits are known for important sites to modify water-mass properties and transport nutrients through vigorous vertical mixing. The first microstructure measurements ever taken in the Tsugaru Strait, betwe...
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Article
Enhanced vertical turbulent nitrate flux in the intermediate layer of the Kuroshio in the Tokara Strait
Vertical mixing in the ocean is an important physical process that brings deep nutrients to the upper layer. The Tokara Strait, where the Kuroshio flows out to the North Pacific from the East China Sea, is kno...
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Article
Enhanced vertical turbulent nitrate flux in the Kuroshio across the Izu Ridge
The first direct measurements of vertical turbulent nitrate flux, FluxNO3, were conducted in the Kuroshio across the Izu Ridge and revealed large FluxNO3 near the sill crest at the 1% light depth. This large Flux
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Article
Long-term outcome of 6-month maintenance chemotherapy for acute lymphoblastic leukemia in children
In the treatment of childhood acute lymphoblastic leukemia (ALL), excess shortening of maintenance therapy resulted in high relapse rate, as shown by our previous trial, TCCSG L92-13, in which maintenance ther...
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Article
IKZF1 deletion is enriched in pediatric B-cell precursor acute lymphoblastic leukemia patients showing prednisolone resistance
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Article
Open AccessValidation of flow cytometric phospho-STAT5 as a diagnostic tool for juvenile myelomonocytic leukemia
To diagnose juvenile myelomonocytic leukemia (JMML) is sometimes challenging, because around 10% of patients lack molecular abnormalities affecting Ras-MAPK (mitogen-activated protein kinase) pathway and other...
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Article
Second allogeneic hematopoietic SCT for relapsed ALL in children
A second SCT is generally accepted as the only potentially curative approach for ALL patients that relapse after SCT, but the role of second SCT for pediatric ALL is not fully understood. We performed a retros...
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Article
Improved outcome of refractory Langerhans cell histiocytosis in children with hematopoietic stem cell transplantation in Japan
Langerhans cell histiocytosis (LCH) that is refractory to conventional chemotherapy has a poor outcome. Hematopoietic stem cell transplanta tion (SCT) is a promising approach for refractory LCH because of its ...
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Article
A case of hemophagocytic lymphohistiocytosis with prolonged remission after syngeneic bone marrow transplantation
We report a 7-year-old girl with hemophagocytic lymphohistiocytosis who received a syngeneic bone marrow transplant from her twin sister. She presented with high fever and cough. Laboratory findings revealed p...
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Article
Allogeneic hematopoietic stem cell transplantation for patients with hemophagocytic syndrome (HPS) in Japan
Seventeen cases (age at onset, 1 month to 18 years; M/F, 9/8) of hemophagocytic syndrome which received allogeneic hematopoietic stem cell transplantation (SCT) in Japan during the period 1988–1998 are reporte...
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Article
Photon and proton activation analysis of iron and steel standards using the internal standard method coupled with the standard addition method
The internal standard method coupled with the standard addition method has been applied to photon activation analysis and proton activation analysis of minor elements and trace impurities in various types of i...