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A novel genetic and morphologic phenotype of ARID2-mediated myelodysplasia
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Donor cell-derived transient abnormal myelopoiesis as a specific complication of umbilical cord blood transplantation
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Open AccessFrequent somatic mutations in epigenetic regulators in newly diagnosed chronic myeloid leukemia
Although tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis of chronic myeloid leukemia (CML), the ability of TKIs to eradicate CML remains uncertain and patients must continue TKI the...
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Article
Long-term outcome of 6-month maintenance chemotherapy for acute lymphoblastic leukemia in children
In the treatment of childhood acute lymphoblastic leukemia (ALL), excess shortening of maintenance therapy resulted in high relapse rate, as shown by our previous trial, TCCSG L92-13, in which maintenance ther...
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Article
Open AccessIdentification of cell-type-specific mutations in nodal T-cell lymphomas
Recent genetic analysis has identified frequent mutations in ten-eleven translocation 2 (TET2), DNA methyltransferase 3A (DNMT3A), isocitrate dehydrogenase 2 (IDH2) and ras homolog family member A (RHOA) in nodal...
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Article
Somatic PHF6 mutations in 1760 cases with various myeloid neoplasms
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Open AccessGenetic basis of myeloid transformation in familial platelet disorder/acute myeloid leukemia patients with haploinsufficient RUNX1 allele
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Clinical and biological implications of ancestral and non-ancestral IDH1 and IDH2 mutations in myeloid neoplasms
Mutations in isocitrate dehydrogenase 1/2 (IDH1/2MT) are drivers of a variety of myeloid neoplasms. As they yield the same oncometabolite, D-2-hydroxyglutarate, they are often treated as equivalent, and pooled. W...
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Article
PRPF8 defects cause missplicing in myeloid malignancies
Mutations of spliceosome components are common in myeloid neoplasms. One of the affected genes, PRPF8, encodes the most evolutionarily conserved spliceosomal protein. We identified either recurrent somatic PRPF8 ...
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Article
Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients
To clarify the cooperative roles of recurrently identified mutations and to establish a more precise risk classification system in acute myeloid leukemia (AML), we comprehensively analyzed mutations in 51 gene...
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Recurrent genetic defects on chromosome 7q in myeloid neoplasms
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Open AccessLandscape of genetic lesions in 944 patients with myelodysplastic syndromes
High-throughput DNA sequencing significantly contributed to diagnosis and prognostication in patients with myelodysplastic syndromes (MDS). We determined the biological and prognostic significance of genetic a...
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Article
Superconducting Molecule Detectors Overcoming Fundamental Limits of Conventional Mass Spectrometry
Mass spectrometry (MS) is widely used in analytical chemistry for such fields as environmental science, life science, and space science. However, MS has two fundamental limits: the mass peak overlap of ions wi...
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Article
Open AccessBeneficial effect of risedronate for preventing recurrent hip fracture in the elderly Japanese women
A 36-month observational study compared the incidence of unaffected side hip fracture in Japanese female osteoporosis patients with a history of hip fracture between 173 patients receiving risedronate and 356 ...
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Clinical impact of cycling the administration of antibiotics for febrile neutropenia in Japanese patients with hematological malignancy
Despite the availability of newer classes of antibiotics, infection with multi-drug-resistant bacteria is a serious problem. To suppress the appearance of multi-drug-resistant bacteria and to avoid severe infe...
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Article
Osteoporotic changes of subchondral trabecular bone in osteoarthritis of the knee: a 3-T MRI study
Subchondral trabecular bone structure was analyzed in knee osteoarthritis (OA) patients using 3-T MRI to investigate structural features of subchondral trabecular bone of knee OA. With OA progression, osteopor...
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Open AccessAnterior chest hump in adolescent idiopathic scoliosis- questionnaire evaluation
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Determination of boron in ceramic reference materials by prompt gamma activation analysis using focused neutron guided beam of JRR-3M
Prompt gamma activation analysis using a focused thermal neutron guided beam at JAEA JRR-3M was applied to the determination of B in ceramic certified reference materials (BAM CRM S-003 Silicon Carbide Powder ...
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Article
Preparation and characterization of organic calibration solutions for development of certified reference materials at the National Metrology Institute of Japan
Certified reference materials (CRMs) are playing an increasingly important role in environmental monitoring in Japan. The National Metrology Institute of Japan (NMIJ)/National Institute of Advanced Industrial ...
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Surgical treatment of intramedullary spinal cord tumors: prognosis and complications
Retrospective case series.