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Article
Allogeneic stem cell transplantation in children with acute lymphoblastic leukemia after isolated central nervous system relapse: our experiences and review of the literature
The prognosis of patients with acute lymphoblastic leukemia (ALL) and central nervous system (CNS) relapse has historically been very poor. Although chemo-radiotherapy has improved outcomes, some patients stil...
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Article
Numerous nonclonal chromosomal aberrations arising in residual recipient hematopoietic cells following allogeneic bone marrow transplantation
A young female patient in a second remission of acute lymphoblastic leukemia underwent bone marrow transplantation after total body irradiation and high-dose cytarabine from her HLA-matched brother. Following ...
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Article
Non-T-cell-depleted HLA haploidentical stem cell transplantation based on feto-maternal microchimerism in pediatric patients with advanced malignancies
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Article
Prolonged hypogammaglobulinemia following rituximab treatment for post transplant Epstein–Barr virus-associated lymphoproliferative disease
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Article
Adenoviral infection in hematopoietic stem cell transplantation: early diagnosis with quantitative detection of the viral genome in serum and urine
Early diagnosis and prompt introduction of effective therapy are imperative to manage systemic, often fatal adenoviral (AdV) disease following hematopoietic stem cell transplantation (SCT). We evaluated the us...
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Article
Acute renal failure due to adenovirus-associated obstructive uropathy and necrotizing tubulointerstitial nephritis in a bone marrow transplant recipient
Management of post-transplant complications caused by severe adenoviral infection remains a major therapeutic challenge. A 17-year-old male who had undergone bone marrow transplantation for the treatment of ac...
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Article
Lack of clinical utility of minimal residual disease detection in allogeneic stem cell recipients with childhood acute lymphoblastic leukemia: multi-institutional collaborative study in Japan
The clinical utility of minimal residual disease (MRD) measurements following allogeneic stem cell transplantation (SCT) in childhood ALL is controversial. We therefore performed a multi-institutional study of...
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Article
A novel infant acute lymphoblastic leukemia cell line with MLL-AF5q31 fusion transcript
Infant acute lymphoblastic leukemia (ALL) is characterized by the presence of the proB phenotype (CD10−/CD19+), poor prognosis and frequent rearrangement of the mixed lineage leukemia (MLL) gene. The most frequen...
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Article
Epstein-Barr virus-associated T-lymphoproliferative disease with hemophagocytic syndrome, followed by fatal intestinal B lymphoma in a young adult female with WHIM syndrome
A rare association of Epstein-Barr virus-associated T- and B-lymphoproliferative disease (EBV+ T- and EBV+ B-LPD) in a patient with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is r...
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Article
FK506-induced intractable leukoencephalopathy following allogeneic bone marrow transplantation
FK506-related leukoencephalopathy has been reported to be reversible and readily treated by discontinuation or reduction of FK506. We describe two pediatric cases of FK506-related leukoencephalopathy following...
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Article
Hematopoietic stem cell transplantation (HSCT) for Langerhans cell histiocytosis (LCH) in Japan
There exists limited information about the usefulness of hemopoietic stem cell transplantation (HSCT) for the treatment of patients with refractory Langerhans cell histiocytosis (LCH). We report here four Japa...
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Article
Allogeneic hematopoietic stem cell transplantation for patients with hemophagocytic syndrome (HPS) in Japan
Seventeen cases (age at onset, 1 month to 18 years; M/F, 9/8) of hemophagocytic syndrome which received allogeneic hematopoietic stem cell transplantation (SCT) in Japan during the period 1988–1998 are reporte...
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Article
Donor lymphocyte infusion at unstable mixed chimerism in an allogeneic BMT recipient for chronic granulomatous disease
We report a 14-year-old boy who had successfully received allogeneic BMT for chronic granulomatous disease and 3 years later was treated with donor lymphocyte infusion (DLI, 3.3 × 108 cells/kg) at unstable mixed ...
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Article
Chimerism analysis on mononuclear cells in the CSF after allogeneic bone marrow transplantation
To evaluate the chimeric status of mononuclear cells in the CSF after allogeneic BMT, cells were analyzed by FISH using satellite DNA probes for human X and Y chromosomes. CSF cells were obtained from five ped...
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Article
Unsuccessful CTL transfusion in a case of post-BMT Epstein–Barr virus-associated lymphoproliferative disorder (EBV-LPD)
A patient with AML (FAB M4Eo) developed EBV-LPD 1.5 months after allogeneic BMT from his one locus-mismatched mother, the diagnosis being confirmed on day +82. Attempts to eradicate the monoclonally proliferat...
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Article
Bone marrow transplatation for Epstein-Barr virus-related clonal T cell proliferation associated with hemophagocytosis
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Article
Distinct mechanism of human neuroblastoma cell adhesion to fibronectin
We investigated the adhesion of three morphologically distinct human neuroblastoma cell lines (NCG, GOTO and SK-N-DZ) to intact fibronectin, central cell binding domain fragment (CBF) and CS peptide-IgG conjug...
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Article
Type I glycogen storage disease with vasoconstrictive pulmonary hypertension
A case of glycogen storage disease (GSD) type I with vasoconstrictive pulmonary hypertension is described.
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Article
131I-Meta-iodobenzylguanidine scintigraphy in patients with neuroblastoma
Twenty-six studies by meta-(131I)-iodobenzylguanidine scintigraphy (131I-MIBG), 26 studies by67Ga-citrate and 3399mTc-hydorxymethylene diphosphate (99mTc-HMDP) scintigraphic studies were performed for 10 patients...
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Chapter
The Enzyme Defects in Hereditary Tyrosinaemia Type I
Two cases of hypertyrosinaemia accompanied by a defect of fumarylacetoacetate fumarylhydrolase (FAH, EC 3.7.12) are described. The deficient FAH activities were found in the liver of one case and in the kidney...
