-
Article
Open AccessRapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ
Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma (PDAC), which commonly occurs in the general populations with aging. Although most PanIN lesions (PanINs) harbor ...
-
Article
Pancreatic Disorders in Patients with Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) can involve multiple organ systems, and pancreatic manifestations of IBD are not uncommon. The incidence of several pancreatic diseases is more frequent in patients with Crohn’...
-
Article
Open AccessInhibition of miR-155 reduces impaired autophagy and improves prognosis in an experimental pancreatitis mouse model
Acute pancreatitis (AP) is a common digestive disease characterized by inflammation of the pancreas. MiR-155 plays a role in promoting inflammation and inhibiting the activation of anti-inflammatory pathways. ...
-
Protocol
Induction of Pancreatic Inflammation Accelerates Pancreatic Tumorigenesis in Mice
Pancreatitis is a major risk factor for the development of pancreatic cancer. In genetically engineered mouse models, induction of pancreatic inflammation dramatically accelerates oncogenic KRas-induced fibros...
-
Article
Open AccessDuctal activation of oncogenic KRAS alone induces sarcomatoid phenotype
Salivary duct carcinoma (SDC) is an uncommon, but aggressive malignant tumor with a high mortality rate. Herein, we reported the detection of somatic KRAS A146T and Q61H mutations in 2 out of 4 (50%) sarcomatoid ...
-
Article
The role of protein synthesis and digestive enzymes in acinar cell injury
The acinar cell of the exocrine pancreas produces, stores and secretes enzymes necessary for the digestion and absorption of food. Here, Logsdon and Ji describe two major stressors of the acinar cell, endoplas...
-
Article
Open AccessIncreased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression
Cell division cycle 20 (CDC20) homolog is an anaphase-promoting complex activator that is essential for cell division, but whether its expression in pancreatic ductal adenocarcinoma (PDAC) is significant is un...
-
Reference Work Entry In depth
Molecular Relationships Between Chronic Pancreatitis and Cancer
Chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) have long been known to be related diseases of the exocrine pancreas, however much of the existing literature is focused on identifying the...
-
Article
HLA-A0201 positive pancreatic cell lines: new findings and discrepancies
Pancreatic cancer is being pursued as an immunotherapy target using antigen-specific vaccine approaches activating CD8+ CTL and CD4+ T-helper cells. CD8+ CTL exert their anti-tumor effects in an HLA-restricted ma...
