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Article

CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci

CRISPR-Cas9 is an efficient and versatile tool for genome engineering in many species. However, inducible CRISPR-Cas9 editing systems that regulate Cas9 activity or sgRNA expression often suffer from significa...

Krzysztof Chylinski, Maria Hubmann, Ruth E. Hanna, Connor Yanchus… in Nature Communications (2019)