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  1. No Access

    Article

    Optineurin is colocalized with ubiquitin in Marinesco bodies

    Claudia Schwab, Sheng Yu, Patrick L. McGeer in Acta Neuropathologica (2012)

  2. Article

    Open Access

    Distinct glutaminyl cyclase expression in Edinger–Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Aβ pathology in Alzheimer’s disease

    Glutaminyl cyclase (QC) was discovered recently as the enzyme catalyzing the pyroglutamate (pGlu or pE) modification of N-terminally truncated Alzheimer’s disease (AD) Aβ peptides in vivo. This modification co...

    Markus Morawski, Maike Hartlage-Rübsamen, Carsten Jäger… in Acta Neuropathologica (2010)

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    Article

    TDP-43 pathology in familial British dementia

    Trans-activation-responsive DNA-binding protein 43 (TDP-43) is a component of pathological inclusions in amyotrophic lateral sclerosis and several forms of sporadic and familial frontotemporal lobar degenerati...

    Claudia Schwab, Tetsuaki Arai, Masato Hasegawa, Haruhiko Akiyama… in Acta Neuropathologica (2009)

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    Chapter

    Inflammatory Processes Exacerbate Degenerative Neurological Disorders

    Evidence that neuroinflammation exacerbates the pathology in Alzheimer’s disease (AD) has been accumulated from three independent fields of research: neuropathology demonstrating activated glial cells, epidemi...

    Patrick L. McGeer, Edith G. McGeer… in Current Hypotheses and Research Milestones… (2009)

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    Article

    Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain

    Familial British dementia (FBD) is characterized neuropathologically by deposition of a unique amyloid-forming protein, ABri. It is a fragment of an abnormal form of a precursor protein, BRI. In FBD, BRI is el...

    Haruhiko Akiyama, Hiromi Kondo, Tetsuaki Arai, Kenji Ikeda… in Acta Neuropathologica (2004)

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    Article

    Familial British dementia: colocalization of furin and ABri amyloid

    Familial British dementia (FBD) is an autosomal dominant condition caused by a point mutation in the stop codon of the BRI gene. This mutation extends the normal precursor protein (PP) of 266 amino acids to the n...

    Claudia Schwab, Masato Hosokawa, Haruhiko Akiyama… in Acta Neuropathologica (2003)

  7. No Access

    Article

    Distinct isoforms of tau aggregated in neurons and glial cells in brains of patients with Pick's disease, corticobasal degeneration and progressive supranuclear palsy

    We investigated isoform composition of aggregated tau protein in brains with Pick's disease (PiD), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) by immunoblot analysis of sarkosyl-i...

    Tetsuaki Arai, Kenji Ikeda, Haruhiko Akiyama, Yasuo Shikamoto… in Acta Neuropathologica (2001)

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    Article

    Pyramidal neuron loss is matched by ghost tangle increase in Guam parkinsonism-dementia hippocampus

    The parkinsonism dementia complex of Guam (bodig disease) is characterized by severe neurofibrillary tangle (NFT) development without the senile plaques which characterize Alzheimer’s disease. Here we analyze...

    Claudia Schwab, John C. Steele, P. L. McGeer in Acta Neuropathologica (1998)

  9. No Access

    Article

    Dystrophic neurites are associated with early stage extracellular neurofibrillary tangles in the parkinsonism-dementia complex of Guam

    We found tangle-associated neuritic clusters (TANCs), previously reported as being present in Alzheimer’s disease (AD), to be common in early and mild cases of the parkinsonism-dementia complex of Guam (PDC, ...

    Claudia Schwab, John C. Steele, P. L. McGeer in Acta Neuropathologica (1997)

  10. No Access

    Article

    Amyloid P immunoreactivity precedes C4d deposition on extracellular neurofibrillary tangles

    Extracellular neurofibrillary tangles (eNFTs) are the insoluble cytoskeletal debris left behind when neurons with intracellular neurofibrillary tangles (iNFTs) die. Reactive microglia and reactive astrocytes ...

    Claudia Schwab, John C. Steele, Edith G. McGeer, P. L. McGeer in Acta Neuropathologica (1996)

  11. No Access

    Article

    Distinct distribution of apolipoprotein E and β-amyloid immunoreactivity in the hippocampus of Parkinson dementia complex of Guam

    The distribution of apolipoprotein E (ApoE) was studied in the brain tissue of cases of the amyotrophic lateral sclerosis – parkinsonism – dementia complex of Guam, locally known as lytico bodig disease (LB),...

    Claudia Schwab, John C. Steele, Haruhiko Akiyama… in Acta Neuropathologica (1996)

  12. No Access

    Article

    Relationship of amyloid β/A4 protein to the neurofibrillary tangles in Guamanian parkinsonism-dementia

    The Chamorro population of the island of Guam is highly susceptible to a disease called lytico-bodig (LB), wich clinically resembles a mixture of amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD) a...

    Claudia Schwab, John C. Steele, Haruhiko Akiyama, Edith G. McGeer… in Acta Neuropathologica (1995)

  13. No Access

    Article

    Different levels of acetylcholinesterase and choline acetyltransferase activities in C57Bl/6 and DBA/2 mice are not accompanied with different density of cortical acetylcholinesterase reactive fibers

    Mice of the inbred strains C57Bl/6 and DBA/2 show strain-dependent behavioural differences which have been correlated with variations in the organization of brain cholinergic systems. The aim of our study was ...

    Claudia Schwab, Gert Brückner, Claudio Castellano… in Neurochemical Research (1990)