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Article
Open AccessNew balance capability index as a screening tool for mild cognitive impairment
Mild cognitive impairment (MCI) is not just a prodrome to dementia, but a very important intervention point to prevent dementia caused by Alzheimer's disease (AD). It has long been known that people with AD ha...
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Chapter
Neuropsychiatry Diseases
Schizophrenia is known as a disorder with a high prevalence in adolescents. Schizophrenia is characterized by positive symptoms such as hallucinations, delusions, thought disorder, and disturbance of self-awar...
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Article
Open AccessChanges in home visit utilization during the COVID-19 pandemic: a multicenter cross-sectional web-based survey
Home care is one of the essential community health care services; thus, identifying changes of home care utilization before and during the COVID-19 pandemic would be useful for researchers and policymaker to r...
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Article
Open AccessExploration of the impact of the COVID-19 pandemic on the mental health of home health care workers in Japan: a multicenter cross-sectional web-based survey
The COVID-19 pandemic has caused home health care workers (home-HCWs) to experience anxiety. The mental health of home-HCWs and related factors during the COVID-19 pandemic have not been clarified; therefore, ...
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Article
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients
Genome-wide association studies have demonstrated that polygenic risks shape Alzheimer’s disease (AD). To elucidate the polygenic architecture of AD phenotypes at a cellular level, we established induced pluri...
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Article
Open AccessIntracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions
TAR DNA-binding protein of 43 kDa (TDP-43) is a major component of intracellular aggregates formed in brains of the patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS...
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Chapter and Conference Paper
Predicting Future Accident Risks of Older Drivers by Speech Data from a Voice-Based Dialogue System: A Preliminary Result
As the world’s elderly population increases, driving accidents involving older adults has become an increasingly serious social problem. Previous studies have suggested cognitive impairments as one of the risk...
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Article
Open AccessThe basis of clinicopathological heterogeneity in TDP-43 proteinopathy
Transactive response DNA-binding protein 43 kDa (TDP-43) was identified as a major disease-associated component in the brain of patients with amyotrophic lateral sclerosis (ALS), as well as the largest subset ...
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Article
Open AccessA novel approach for assessing neuromodulation using phase-locked information measured with TMS-EEG
Neuromodulation therapies such as electroconvulsive therapy (ECT) are used to treat several neuropsychiatric disorders, including major depressive disorder (MDD). Recent work has highlighted the use of combine...
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Chapter and Conference Paper
Effects of Age-Related Cognitive Decline on Elderly User Interactions with Voice-Based Dialogue Systems
Cognitive functioning that affects user behaviors is an important factor to consider when designing interactive systems for the elderly, including emerging voice-based dialogue systems such as smart speakers a...
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Chapter
Progranulin and Frontotemporal Lobar Degeneration
Granulin (GRN) mutations were first found in frontotemporal dementia (FTD) patients with ubiquitin-positive, tau-negative inclusions in 2006. These inclusions were also found to contain a TAR-DNA binding protein ...
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Article
Open AccessPotent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods
The concept that abnormal protein aggregates show prion-like propagation between cells has been considered to explain the onset and progression of many neurodegenerative diseases. Indeed, both synthetic amyloi...
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Article
Open AccessAccumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation
In 2006, mutations in the granulin gene were identified in patients with familial Frontotemporal Lobar Degeneration. Granulin transcript haploinsufficiency has been proposed as a disease mechanism that leads t...
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Article
Inositol Hexakisphosphate Kinase 2 Promotes Cell Death in Cells with Cytoplasmic TDP-43 Aggregation
TAR DNA-binding protein 43 (TDP-43) has been identified as a major component of ubiquitin-positive inclusions in the brains and spinal cords of patients with frontotemporal lobar degeneration with ubiquitinate...
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Article
Open AccessChorea as a clinical feature of the basophilic inclusion body disease subtype of fused-in-sarcoma-associated frontotemporal lobar degeneration
Choreoathetoid involuntary movements are rarely reported in patients with frontotemporal lobar degeneration (FTLD), suggesting their exclusion as a supportive feature in clinical diagnostic criteria for FTLD. ...
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Article
Open AccessBiochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau
Intracellular filamentous tau pathology is the defining feature of tauopathies, which form a subset of neurodegenerative diseases. We have analyzed pathological tau in Alzheimer’s disease, and in frontotempora...
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Article
Open AccessTau accumulation in the nucleus accumbens in tangle-predominant dementia
Tangle-predominant dementia (TPD) is characterized neuropathologically by numerous neurofibrillary tangles in the limbic areas with no or occasional senile plaques throughout the brain. TPD is an under-recogni...
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Article
Open AccessReducing TDP-43 aggregation does not prevent its cytotoxicity
TAR DNA-binding protein 43 (TDP-43) is a protein that is involved in the pathology of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). In patients with these neurodegenerative ...
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Article
Molecular Dissection of TDP-43 Proteinopathies
TDP-43 has been identified as a major component of ubiquitin-positive tau-negative cytoplasmic inclusions in frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and in amyotrophic lat...
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Article
Effect of topographical distribution of α-synuclein pathology on TDP-43 accumulation in Lewy body disease
It has been reported that the development of TDP-43 pathology in cases of Lewy body disease (LBD) might be associated with the severity of tau pathology. However, the impact of α-synuclein pathology on TDP-43 ...
