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Article
Open AccessA global multicohort study to map subcortical brain development and cognition in infancy and early childhood
The human brain grows quickly during infancy and early childhood, but factors influencing brain maturation in this period remain poorly understood. To address this gap, we harmonized data from eight diverse co...
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Article
Open AccessMaternal exposure to childhood maltreatment and adverse birth outcomes
Exposure to traumatic events during pregnancy may influence pregnancy and birth outcomes. Growing evidence suggests that exposure to traumatic events well before pregnancy, such as childhood maltreatment (CM),...
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Article
Open AccessMaternal pre-pregnancy body mass index is associated with newborn offspring hypothalamic mean diffusivity: a prospective dual-cohort study
An extensive body of animal literature supports the premise that maternal obesity during pregnancy can alter the development of the fetal hypothalamus (HTH, a critical regulator of energy balance) with implica...
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Article
Trajectories of depressive symptoms among mothers of preterm and full-term infants in a national sample
To examine postpartum depressive symptom trajectories from birth to age 5 and their risk factors in a national sample of mothers of preterm and full-term infants. The racially and ethnically diverse sample com...
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Article
Open AccessHow biomarker patterns can be utilized to identify individuals with a high disease burden: a bioinformatics approach towards predictive, preventive, and personalized (3P) medicine
Prevalences of non-communicable diseases such as depression and a range of somatic diseases are continuously increasing requiring simple and inexpensive ways to identify high-risk individuals to target with pr...
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Intergenerational Transmission of Parental Early Life Stress
Early life stress (ELS) has well-established consequences for health and disease risk of the exposed individual. Emerging evidence now suggests that the sequelae of ELS may be transmitted across generations, t...
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Article
Open AccessIntegrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated eithe...
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Article
Antenatal depression, psychotropic medication use, and inflammation among pregnant women
To evaluate the association between psychotropic medication and inflammatory biomarkers in women with antenatal depressive symptoms (ADS). In this cross-sectional secondary analysis of a prospective multicente...
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Article
Stress during pregnancy and gestational weight gain
To evaluate the association between prenatal stress and gestational weight gain (GWG).
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Article
Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring
Several lines of evidence support the link between maternal inflammation during pregnancy and increased likelihood of neurodevelopmental and psychiatric disorders in offspring. This longitudinal study seeks to...
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Article
Association between supraclavicular brown adipose tissue composition at birth and adiposity gain from birth to 6 months of age
Brown adipose tissue (BAT) is associated with higher energy expenditure and lower adiposity in adults. However, the relationship between BAT composition and adiposity in early life is unknown. The objective of...
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Article
Frühe Stresserfahrungen und Krankheitsvulnerabilität
Das stetig wachsende Forschungsgebiet der „Frühe[n] Programmierung von Krankheit und Gesundheit“ untersucht, inwieweit die individuelle Vulnerabilität für die Entstehung verschiedenster Erkrankungen über die L...
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Article
ADHD and cannabis use in young adults examined using fMRI of a Go/NoGo task
Children diagnosed with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for substance abuse. Response inhibition is a hallmark of ADHD, yet the combined effects of ADHD and regular substa...
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Article
Die Bedeutung früher traumatischer Lebenserfahrungen
Traumatische Erfahrungen im Kindesalter sind wichtige Risikofaktoren für psychische und körperliche Erkrankungen im Erwachsenenalter. Langfristige neuroendokrine, immunologische und neurale Folgen früher Stres...
