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Open AccessSex differences in DNA methylation across gestation: a large scale, cross-cohort, multi-tissue analysis
Biological sex is a key variable influencing many physiological systems. Disease prevalence as well as treatment success can be modified by sex. Differences emerge already early in life and include pregnancy c...
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Article
Open AccessA global multicohort study to map subcortical brain development and cognition in infancy and early childhood
The human brain grows quickly during infancy and early childhood, but factors influencing brain maturation in this period remain poorly understood. To address this gap, we harmonized data from eight diverse co...
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Article
Open AccessMaternal exposure to childhood maltreatment and adverse birth outcomes
Exposure to traumatic events during pregnancy may influence pregnancy and birth outcomes. Growing evidence suggests that exposure to traumatic events well before pregnancy, such as childhood maltreatment (CM),...
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Open AccessEarly-life adversities and later-life reproductive patterns in women with fully traced reproductive history
One of the most crucial determinants of early-life development is the experience of childhood adversities. However, limited evidence is available for how these experiences shape later-life reproductive outcome...
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Article
Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure
Obesity is caused by a prolonged positive energy balance1,2. Whether reduced energy expenditure stemming from reduced activity levels contributes is debated3,4. Here we show that in both sexes, total energy expen...
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Open AccessMaternal pre-pregnancy body mass index is associated with newborn offspring hypothalamic mean diffusivity: a prospective dual-cohort study
An extensive body of animal literature supports the premise that maternal obesity during pregnancy can alter the development of the fetal hypothalamus (HTH, a critical regulator of energy balance) with implica...
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Open AccessReliability of a novel approach for reference-based cell type estimation in human placental DNA methylation studies
The placenta is a central organ during early development, influencing trajectories of health and disease. DNA methylation (DNAm) studies of human placenta improve our understanding of how its function relates ...
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Article
Open AccessTotal energy expenditure is repeatable in adults but not associated with short-term changes in body composition
Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examin...
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Open AccessBetamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation
Glucocorticoids (GCs) play a pivotal role in fetal programming. Antenatal treatment with synthetic GCs (sGCs) in individuals in danger of preterm labor is common practice. Adverse short- and long-term effects ...
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Article
Open AccessIntergenerational transmission of health disparities among Turkish-origin immigrants in Germany: study protocol of a multi-centric cohort study (BaBi-stress and BaBeK study)
Immigrants in Germany exhibit higher levels of social disadvantage when compared to the non-immigrated population. Turkish-origin immigrants constitute an important immigrant group in Germany and show disparit...
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Open AccessIntegrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated eithe...
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Article
Antenatal depression, psychotropic medication use, and inflammation among pregnant women
To evaluate the association between psychotropic medication and inflammatory biomarkers in women with antenatal depressive symptoms (ADS). In this cross-sectional secondary analysis of a prospective multicente...
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Stress during pregnancy and gestational weight gain
To evaluate the association between prenatal stress and gestational weight gain (GWG).
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Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring
Several lines of evidence support the link between maternal inflammation during pregnancy and increased likelihood of neurodevelopmental and psychiatric disorders in offspring. This longitudinal study seeks to...
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Article
Association between supraclavicular brown adipose tissue composition at birth and adiposity gain from birth to 6 months of age
Brown adipose tissue (BAT) is associated with higher energy expenditure and lower adiposity in adults. However, the relationship between BAT composition and adiposity in early life is unknown. The objective of...
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Open AccessMeasurement of cortisol in saliva: a comparison of measurement error within and between international academic-research laboratories
Hundreds of scientific publications are produced annually that involve the measurement of cortisol in saliva. Intra- and inter-laboratory variation in salivary cortisol results has the potential to contribute ...
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Article
Frühe Stresserfahrungen und Krankheitsvulnerabilität
Das stetig wachsende Forschungsgebiet der „Frühe[n] Programmierung von Krankheit und Gesundheit“ untersucht, inwieweit die individuelle Vulnerabilität für die Entstehung verschiedenster Erkrankungen über die L...
