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Article
Proansamycin B derivatives from the post-PKS modification gene deletion mutant of Amycolatopsis mediterranei S699
Ten new proansamycin B congeners (1–10) together with one known (11) were isolated and characterized on the basis of 1D and 2D NMR spectroscopic and HRESIMS data from the Amycolatopsis mediterranei S699 ΔPM::rifR
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Article
Study on Coupled Vibration of Human-plate System under Pedestrian Excitation
In the paper, in order to explore the influence of human-structure interaction (HSI) in the vertical direction on the dynamic response of floors due to human-induced excitation, the formula for the human-plate...
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Article
Built-in electric field-assisted heterostructure electrolyte based on K2NiF4-type La2NiO4 for solid oxide fuel cells
The reduction of the operating temperatures of solid oxide fuel cells (SOFCs) has attracted global research attention and inspired considerable efforts toward the development of new materials for low-temperatu...
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Article
Open AccessIn situ continuous Dopa supply by responsive artificial enzyme for the treatment of Parkinson’s disease
Oral dihydroxyphenylalanine (Dopa) administration to replenish neuronal dopamine remains the most effective treatment for Parkinson’s disease (PD). However, unlike the continuous and steady dopamine signaling ...
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Article
Selecting small molecule DNA aptamers with significant conformational changes for constructing transcriptional switches and biosensors
Small molecule aptamers discovered by traditional selection methods usually lack conformational changes upon target binding. This limits the use of aptamers as molecular probes for small molecule detection and...
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Article
Open AccessOvercoming adaptive resistance to anti-VEGF therapy by targeting CD5L
Antiangiogenic treatment targeting the vascular endothelial growth factor (VEGF) pathway is a powerful tool to combat tumor growth and progression; however, drug resistance frequently emerges. We identify CD5L...
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Article
Enhanced photostability of chlorophyll by introducing Mg2Si as an O2-depleting agent
The application of chlorophyll (Chl) is limited due to its low photostability. The regulation of oxygen status including both oxygen (O2) and singlet oxygen (1O2) around Chl molecules is important to improve thei...
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Article
Open AccessPELI1 and EGFR cooperate to promote breast cancer metastasis
Pellino-1 (PELI1) is an E3 ubiquitin ligase acting as a key regulator for the inflammation and autoimmunity via the ubiquitination of the substrate proteins. There is increasing evidence to support that PELI1 ...
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Chapter and Conference Paper
Research on Financial Risk Analysis of Nuclear Power Project Based on Monte Carlo Simulation
Taking the economic evaluation method of nuclear power plant construction projects as the basic model, the profitability index commonly used in financial analysis as economic evaluation index, the typical prob...
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Chapter and Conference Paper
Research on Calculation Method and Additionality of Carbon Emission Reduction of Nuclear Energy Heating Based on Project Perspective
Nuclear energy has broad prospects for development driven by the goal of achieving peak carbon emissions and carbon neutrality, but the independent contribution of nuclear energy in low-carbon development has ...
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Article
Dual inhibition of glycolysis and oxidative phosphorylation by aptamer-based artificial enzyme for synergistic cancer therapy
Dual inhibition of glycolysis and oxidative phosphorylation (OXPHOS) can break the metabolic plasticity of cancer cells to inhibit most energy supply and lead to effective cancer therapy. However, the pharmaco...
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Article
Bridging localized electron states of pyrite-type CoS2 cocatalyst for activated solar H2 evolution
The development of low-cost and high-active cocatalysts is one of the most significant links for photocatalytic water splitting. Herein, a novel strategy of electron delocalization modulation for transition me...
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Article
Author Correction: Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
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Article
Nucleic Acids Analysis
Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysi...
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Article
Embedding of stereo molecular scaffold into the planar g-C3N4 nanosheets for efficient photocatalytic hydrogen evolution under ordinary pressure
Graphitic carbon nitride (g-C3N4), as an organic polymer semiconductor, has been the focus of photocatalysts due to its physical and chemical stability, low cost and non-toxicity. However, pristine g-C3N4 also ha...
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Article
Shale gas production in nanoscale fractures with real gas effect
Shale gas is the key focus of energy development in the twenty-first century. The physical characteristics of shale gas include microscale effect, mixed gas effect (MGE), and real gas effect (RGE). In addition...
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Article
Open AccessAuthor Correction: Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Modeling of Borehole Hydraulic Fracture Initiation and Propagation with Pre-existing Cracks Using the Displacement Discontinuity Method
Pre-existing borehole cracks result in hydraulic fracture deflection, which causes sand screen-out in advance and even fracturing failure. Based on a simplified three-dimensional displacement discontinuity met...
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Chapter and Conference Paper
Identifying Key Learner on Online E-Learning Platform: An Effective Resistance Distance Approach
Teachers are never the only teacher in the class, especially in online e-learning environment. The key learner who is supposed to be more active and eager to spread knowledge and motivation to other classmates...
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Article
Luminescent and hydrophobic textile coatings with recyclability and self-healing capability against both chemical and physical damage
Luminescent and hydrophobic textile coatings with recyclability and self-healing capability against both chemical and physical damage were prepared, which present multi-functions and long service life cycles. ...
