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  1. No Access

    Article

    Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3

    Allelic loss at the short arm of chromosome 3 is one of the most common and earliest events in the pathogenesis of lung cancer, and is observed in more than 90% of small-cell lung cancers (SCLCs) and in 50–80%...

    Reinhard Dammann, Chun Li, Jung-Hoon Yoon, Philip L. Chin, Steven Bates… in Nature Genetics (2000)

  2. No Access

    Article

    Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1

    Wei Zheng and colleagues carried out a genome-wide association study of breast cancer in Chinese women and discovered risk variants on 6q25.1 located upstream of the gene encoding estrogen receptor 1 (ESR1). They...

    Wei Zheng, Jirong Long, Yu-Tang Gao, Chun Li, Ying Zheng, Yong-Bin **ang… in Nature Genetics (2009)

  3. No Access

    Article

    Genome-wide association identifies multiple ulcerative colitis susceptibility loci

    Mark Seielstad and colleagues report results of a large genome-wide association and replication study of ulcerative colitis. The work identifies several new risk loci for this disease and provides further insi...

    Dermot P B McGovern, Agnès Gardet, Leif Törkvist, Philippe Goyette… in Nature Genetics (2010)

  4. Article

    Erratum: Genome-wide association identifies multiple ulcerative colitis susceptibility loci

    Nat. Genet. 42, 332–337 (2010); published online 14 March 2010; corrected after print 29 March 2011 In the version of this article initially published, Kathryn Roeder's affiliation was incorrect. Her correct a...

    Dermot P B McGovern, Agnès Gardet, Leif Törkvist, Philippe Goyette… in Nature Genetics (2011)

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  5. No Access

    Article

    Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population

    Qing Wang and colleagues report a genome-wide association study for coronary artery disease (CAD) in a Chinese Han population. They identify a locus on chromosome 6p24.1 newly associated with CAD.

    Fan Wang, Cheng-Qi Xu, Qing He, Jian-** Cai, **u-Chun Li, Dan Wang… in Nature Genetics (2011)

  6. No Access

    Article

    Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia

    Hamish Scott and colleagues report that germline mutations in GATA2 segregate with myelodysplastic syndrome and acute myeloid leukemia in four pedigrees. The resulting alterations occur in a conserved zinc finger...

    Christopher N Hahn, Chan-Eng Chong, Catherine L Carmichael… in Nature Genetics (2011)

  7. No Access

    Article

    Meta-analysis identifies common variants associated with body mass index in east Asians

    **ao-Ou Shu and colleagues report a meta-analysis of genome-wide association studies for body mass index (BMI) in east Asians. They identify three new genetic loci associated with BMI.

    Wanqing Wen, Yoon-Shin Cho, Wei Zheng, Rajkumar Dorajoo, Norihiro Kato… in Nature Genetics (2012)

  8. No Access

    Article

    The growth factor SVH-1 regulates axon regeneration in C. elegans via the JNK MAPK cascade

    Following axonal injury in C. elegans, the growth factor SVH-1 and its cognate receptor tyrosine kinase, SVH-2, act to promote axonal regeneration via activation of the JNK-MAPK pathway.

    Chun Li, Naoki Hisamoto, Paola Nix, Shuka Kanao, Tomoaki Mizuno… in Nature Neuroscience (2012)

  9. No Access

    Article

    Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk

    Wei Zheng and colleagues report the results of a large-scale genome-wide association study of colorectal cancer in East Asians. They identify six new susceptibility loci, including variants near TCF7L2 and TGFB1.

    Ben Zhang, Wei-Hua Jia, Koichi Matsuda, Sun-Seog Kweon, Keitaro Matsuo… in Nature Genetics (2014)

  10. No Access

    Article

    Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1

    Qiuyin Cai and colleagues report a genome-wide association analysis for breast cancer in 22,780 cases and 24,181 controls from 14 studies as part of the Asia Breast Cancer Consortium. They identify three loci ...

    Qiuyin Cai, Ben Zhang, Hyuna Sung, Siew-Kee Low, Sun-Seog Kweon, Wei Lu… in Nature Genetics (2014)