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Article
Open AccessZSWIM8 is a myogenic protein that partly prevents C2C12 differentiation
Cell adhesion molecule-related/downregulated by oncogenes (Cdon) is a cell-surface receptor that mediates cell–cell interactions and positively regulates myogenesis. The cytoplasmic region of Cdon interacts wi...
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Article
Open AccessPhosphatidylserine exposure mediated by ABC transporter activates the integrin signaling pathway promoting axon regeneration
Following axon injury, a cascade of signaling events is triggered to initiate axon regeneration. However, the mechanisms regulating axon regeneration are not well understood at present. In Caenorhabditis elegans,...
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Article
Open AccessAxotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans
The molecular mechanisms underlying the ability of axons to regenerate after injury remain poorly understood. Here we show that in Caenorhabditis elegans, axotomy induces ectopic expression of serotonin (5-HT) in...
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Article
Open AccessEndocannabinoid-Goα signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gqα-PKC-JNK signalling
The ability of neurons to regenerate their axons after injury is determined by a balance between cellular pathways that promote and those that inhibit regeneration. In Caenorhabditis elegans, axon regeneration is...
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Article
The growth factor SVH-1 regulates axon regeneration in C. elegans via the JNK MAPK cascade
Following axonal injury in C. elegans, the growth factor SVH-1 and its cognate receptor tyrosine kinase, SVH-2, act to promote axonal regeneration via activation of the JNK-MAPK pathway.
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Article
An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans
In the nematode Caenorhabditis elegans, the gonad acquires two U-shaped arms through the directed migration of its distal tip cells (DTCs), which are located at the tip of the growing gonad arms1. A member of the...
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Article
MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans
The signalling protein Wnt regulates transcription factors containing high-mobility-group (HMG) domains to direct decisions on cell fate during animal development1. In Caenorhabditis elegans, the HMG-domain-conta...
