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Article
The pathobiology of human fungal infections
Human fungal infections are a historically neglected area of disease research, yet they cause more than 1.5 million deaths every year. Our understanding of the pathophysiology of these infections has increased...
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Article
Open AccessCandida albicans Cdc15 is essential for mitotic exit and cytokinesis
Candida albicans displays a variety of morphological forms, and the ability to switch forms must be linked with cell cycle control. In budding yeast the Mitotic Exit Network (MEN) acts to drive mitotic exit and s...
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Article
Open AccessRole of the Candida albicans MNN1 gene family in cell wall structure and virulence
The Candida albicans cell wall is the first point of contact with the host, and its outer surface is heavily enriched in mannoproteins modified through the addition of N- and O-mannan. Previous work, using mutant...
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Article
Open AccessEvolution of pathogenicity and sexual reproduction in eight Candida genomes
Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There a...
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Article
Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3
Allelic loss at the short arm of chromosome 3 is one of the most common and earliest events in the pathogenesis of lung cancer, and is observed in more than 90% of small-cell lung cancers (SCLCs) and in 50–80%...
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Chapter and Conference Paper
Gene Transfer by Bacterial Conjugation: Establishment of the Immigrant Plasmid in the Recipient Cell
Bacterial plasmids are extrachromosomal DNA elements that replicate autonomously in their host cells. In addition to containing sectors for replication and maintenance stability, plasmids collectively carry di...
