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Article
Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy
Kirsten rat sarcoma virus (KRAS) signaling drives pancreatic ductal adenocarcinoma (PDAC) malignancy, which is an unmet clinical need. Here, we identify a disintegrin and metalloproteinase domain (ADAM)9 as a ...
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Article
Segmental Duodenal Resection for Gastrointestinal Stromal Tumor
Surgical management of duodenal gastrointestinal stromal tumors (GIST) remains challenging due to the anatomical complexity of the region. While pancreaticoduodenectomy is considered standard, it is associated...
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Article
Open AccessThe effects of regular dental scaling on the complications and mortality after stroke: a retrospective cohort study based on a real-world database
Previous observational studies have shown that people with dental scaling (DS) had decreased risk of stroke. However, limited information is available on the association between DS and poststroke outcomes. The...
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Article
Open AccessAdverse outcomes after non-hepatic surgeries in patients with alcoholic liver diseases: a propensity-score matched study
The influence of alcoholic liver disease (ALD) on the postoperative outcomes is not completely understood. Our purpose is to evaluate the complications and mortality after nonhepatic surgeries in patients with...
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Article
Open AccessRisk factors related to age at diagnosis of pancreatic cancer: a retrospective cohort pilot study
Increased pancreatic cancer incidence has been observed among younger than in older adults. This pilot study aimed to determine the feasibility of a large study that would compare the age at diagnosis of pancr...
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Article
Open AccessEndoscopic ultrasound-guided fine-needle biopsy as a tool for studying the intra-tumoral microbiome in pancreatic ductal adenocarcinoma: a pilot study
A new approach by investigating the intra-tumoral microbiome raised great interest because they may influence the host immune response and natural history of the disease. However, previous studies on the intra...
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Article
Open AccessRisk of acute atherosclerotic cardiovascular disease in patients with acute and chronic pancreatitis
The association between pancreatitis and acute myocardial infarction or stroke remains incompletely understood. This study aimed to evaluate the long-term risk of acute atherosclerotic cardiovascular disease (...
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Article
Open AccessPredicting microvascular invasion in hepatocellular carcinoma: a deep learning model validated across hospitals
The accuracy of estimating microvascular invasion (MVI) preoperatively in hepatocellular carcinoma (HCC) by clinical observers is low. Most recent studies constructed MVI predictive models utilizing radiologic...
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Article
Open AccessAdverse outcomes after noncardiac surgery in patients with aortic stenosis
Whether aortic stenosis (AS) increases perioperative risk in noncardiac surgery remains controversial. Limited information is available regarding adequate anesthetic techniques for patients with AS. Using the ...
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Article
Open AccessRisk and outcomes of diabetes in patients with epilepsy
The risk and outcomes of diabetes in patients with epilepsy remains unclear. We evaluated these risks using an epilepsy cohort analysis and a diabetes admission analysis. In the epilepsy cohort analysis, we id...
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Article
Open AccessSepticemia and mortality after noncardiac surgery associated with CHA2DS2-VASc score: a retrospective cohort study based on a real-world database
Little was know about the association between the CHA2DS2-VASc score and postoperative outcomes. Our purpose is to evaluate the effects of CHA2DS2-VASc score on the perioperative outcomes in patients with atri...
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Article
Open AccessA population-based cohort study of mortality of intensive care unit patients with liver cirrhosis
The impact of liver cirrhosis on the outcomes of admission to intensive care unit (ICU) is not completely understood. Our purpose is to identify risk factors for mortality in ICU patients with liver cirrhosis.
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Article
Laparoscopic Liver Resection: Experience of 436 Cases in One Center
To report experience of laparoscopic liver resection (LLR) in one center.
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Article
Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques
The transplantation of pancreatic islet cells could restore glycaemic control in patients with type 1 diabetes. Microspheres for islet encapsulation have enabled long-term glycaemic control in rodent models of...
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Article
Open AccessThe prevalence, characteristics, and factors associated with purchasing Chinese herbal medicine among adults in Taiwan
The objective of this study was to investigate the prevalence and factors associated with purchasing Chinese herbal medicine (CHM) without a physician’s prescription among adults.
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Article
Open AccessAn investigation of the use of acupuncture in stroke patients in Taiwan: a national cohort study
Acupuncture is considered a complementary and alternative medicine in many countries. The purpose of this study was to report the pattern of acupuncture use and associated factors in patients with stroke.
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Article
Open AccessDecreased risk of acute myocardial infarction in stroke patients receiving acupuncture treatment: a nationwide matched retrospective cohort study
Whether acupuncture protects stroke patients from acute myocardial infarction (AMI) has not been studied previously. The purpose of this study was to investigate the risk of AMI among stroke patients receiving...
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Article
Hepatic Resection for Hepatocellular Carcinoma Patients on Hemodialysis for Uremia: A Nationwide Cohort Study
The association between uremia and survival outcomes of patients undergoing hepatic resection for hepatocellular carcinoma (HCC) has not been well investigated, particularly for perioperative complications. Th...
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Article
Laparoscopic appendectomy for acute appendicitis is more favorable for patients with comorbidities, the elderly, and those with complicated appendicitis: a nationwide population-based study
Laparoscopic appendectomy (LA) is not routinely performed for appendicitis because the costs associated with that procedure are higher than those for open appendectomy (OA). However, few studies have investiga...
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Article
Laparoscopic Simple Closure Alone is Adequate for Low Risk Patients with Perforated Peptic Ulcer
Helicobacter pylori (H.P.) eradication has led to a significant decline in peptic ulcer prevalence; however, the number of patients requiring surgical intervention remains relatively u...
