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Open AccessAggregation promotes charge separation in fullerene-indacenodithiophene dyad
Fast photoinduced charge separation (CS) and long-lived charge-separated state (CSS) in small-molecules facilitate light-energy conversion, while simultaneous attainment of both remains challenging. Here we ac...
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Article
Open AccessThymoquinone as an electron transfer mediator to convert Type II photosensitizers to Type I photosensitizers
The development of Type I photosensitizers (PSs) is of great importance due to the inherent hypoxic intolerance of photodynamic therapy (PDT) in the hypoxic microenvironment. Compared to Type II PSs, Type I PS...
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Article
Open AccessConnective tissue inspired elastomer-based hydrogel for artificial skin via radiation-indued penetrating polymerization
Robust hydrogels offer a candidate for artificial skin of bionic robots, yet few hydrogels have a comprehensive performance comparable to real human skin. Here, we present a general method to convert tradition...
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Open AccessDevelopment of machine learning prognostic models for overall survival of prostate cancer patients with lymph node-positive
Prostate cancer (PCa) patients with lymph node involvement (LNI) constitute a single-risk group with varied prognoses. Existing studies on this group have focused solely on those who underwent prostatectomy (R...
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Article
Open AccessTruck platooning reshapes greenhouse gas emissions of the integrated vehicle-road infrastructure system
Reducing greenhouse gas emissions has turned into a pillar of climate change mitigation. Truck platooning is proposed as a strategy to lower emissions from vehicles on roads. However, the potential interactive...
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Open AccessArtificial reefs reduce the adverse effects of mud and transport stress on behaviors of the sea cucumber Apostichopus japonicus
Poor survival of seeds reduces the production efficiency of the sea cucumber Apostichopus japonicus in pond culture. We investigated the effects of sea mud on the movement-related behaviors of A. japonicus with d...
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Open AccessGenome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study o...
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Open AccessRectifying disorder of extracellular matrix to suppress urethral stricture by protein nanofilm-controlled drug delivery from urinary catheter
Urethral stricture secondary to urethral injury, afflicting both patients and urologists, is initiated by excessive deposition of extracellular matrix in the submucosal and periurethral tissues. Although vario...
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Open AccessTRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca2+ leakage
Intracellular Ca2+ dysregulation is a key marker in septic cardiac dysfunction; however, regulation of the classic Ca2+ regulatory modules cannot successfully abolish this symptom. Here we show that the knockout ...
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Article
Open AccessMiniature optoelectronic compound eye camera
Inspired by insect compound eyes (CEs) that feature unique optical schemes for imaging, there has recently been growing interest in develo** optoelectronic CE cameras with comparable size and functions. Howe...
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Article
Open AccessTranscriptomes reveal the involved genes in the sea urchin Mesocentrotus nudus exposed to high flow velocities
Despite the importance of flow velocity in marine ecosystems, molecular mechanisms of the water flow induced behavioral and growth changes remain largely unknown in sea urchins. The present study compared the ...
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Clinical application of a 5G-based telerobotic ultrasound system for thyroid examination on a rural island: a prospective study
To evaluate the feasibility of a 5G-based telerobotic ultrasound (US) system for thyroid examination on a rural island.
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Article
Olfactory sensory experience regulates gliomagenesis via neuronal IGF1
Animals constantly receive various sensory stimuli, such as odours, sounds, light and touch, from the surrounding environment. These sensory inputs are essential for animals to search for food and avoid predat...
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Article
Map** genomic loci implicates genes and synaptic biology in schizophrenia
Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 con...
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Article
Open AccessReconstructed covalent organic frameworks
Covalent organic frameworks (COFs) are distinguished from other organic polymers by their crystallinity1–3, but it remains challenging to obtain robust, highly crystalline COFs because the framework-forming react...
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Article
Open AccessAerobic exercise promotes the expression of ATGL and attenuates inflammation to improve hepatic steatosis via lncRNA SRA
The role of aerobic exercise in preventing and improving non-alcoholic fatty liver has been widely established. SRA is a long non-coding RNA, which has received increasing attention due to its important role i...
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Structural insights into Ubr1-mediated N-degron polyubiquitination
The N-degron pathway targets proteins that bear a destabilizing residue at the N terminus for proteasome-dependent degradation1. In yeast, Ubr1—a single-subunit E3 ligase—is responsible for the Arg/N-degron pathw...
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Open AccessHealth-related quality of life and its related factors in coronary heart disease patients: results from the Henan Rural Cohort study
The aims were to identify the possible influencing factors of health-related quality of life (HRQoL) and its domain-specific scores in patients with coronary heart disease (CHD). A total of 1247 patients with ...
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Article
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a respiratory disease called coronavirus disease 2019 (COVID-19), the spread of which has led to a pandemic. An effective preventive vaccine ...
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Open AccessExtracellular polysaccharide synthesis in a bloom-forming strain of Microcystis aeruginosa: implications for colonization and buoyancy
Microcystis, the dominant species among cyanobacterial blooms, normally forms colonies under natural conditions but exists as single cells or paired cells in axenic laboratory cultures after long-term cultivation...