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Article
Open AccessCorrelation between newborn weight and serum BCAAs in pregnant women with diabetes
Branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, are essential amino acids for mammals. Maternal BCAAs during pregnancy have been associated with newborn development. Meanwhile, B...
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Article
Open AccessInterferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells
The bioactivity of interferon-γ (IFN-γ) in cancer cells in the tumor microenvironment (TME) is not well understood in the current immunotherapy era. We found that IFN-γ has an immunosuppressive effect on color...
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Article
Liraglutide Improves PCOS Symptoms in Rats by Targeting FDX1
Polycystic ovary syndrome (PCOS) is a gynecological endocrine disorder characterized by ovulatory disorders, hyperandrogenemia, and polycystic changes in the ovaries. FDX1 is a ferredoxin-reducing protein on h...
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Article
Open AccessTissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans
Ageing exhibits common and distinct features in various tissues, making it critical to decipher the tissue-specific ageing mechanisms. MiRNAs are essential regulators in ageing and are recently highlighted as ...
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Article
Molecular basis and engineering of miniature Cas12f with C-rich PAM specificity
CRISPR–Cas12f nucleases are currently one of the smallest genome editors, exhibiting advantages for efficient delivery via cargo-size-limited adeno-associated virus delivery vehicles. Most characterized Cas12f...
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Article
Murine Cytomegalovirus Infection Induced miR-1929-3p Down-Regulation Promotes the Proliferation and Apoptosis of Vascular Smooth Muscle Cells in Mice by Targeting Endothelin A Receptor and Downstream NLRP3 Activation Pathway
Our previous study demonstrated in vivo that mouse cytomegalovirus (MCMV) infection promoted vascular remodeling after downregulation of miR-1929-3p. This study aimed to investigate the role of miR-1929-3p/ETA...
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Article
China’s Campaign-Style Implementation Regime: How is “Targeted Poverty Alleviation” being achieved locally?
By integrating policy regimes and campaign theories, this article investigates the institutional mode by which China’s local governments transcend their structural-interest constraints and overcome their capac...
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Article
Open AccessHigh-efficiency targeted transgene integration via primed micro-homologues
Due to the difficulties in precisely manipulating DNA repair pathways, high-fidelity targeted integration of large transgenes triggered by double-strand breaks is inherently inefficient. Here, we exploit prime...
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Article
Open AccessPrimary cilia support cartilage regeneration after injury
In growing children, growth plate cartilage has limited self-repair ability upon fracture injury always leading to limb growth arrest. Interestingly, one type of fracture injuries within the growth plate achie...
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Article
Co-occurrence of polyneuritis crainials and visual impairment: a case report and literature review
Polyneuritis cranialis (PNC) with the disease characteristics of Guillain-Barré syndrome (GBS) in addition to both ocular and bulbar weakness in the absence of limb paralysis or ataxia is defined as an unusual...
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Article
A new q-supercongruence modulo the fourth power of a cyclotomic polynomial
Employing the q-WZ method, Guo and Wang gave a q-analogue of a supercongruence modulo \(p^4\) ...
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Article
Low expression of miR-1929-3p mediates murine cytomegalovirus-induced fibrosis in cardiac fibroblasts via targeting endothelin a receptor/NLRP3 inflammasome pathway
MicroRNAs are crucial in the development of myocardial remodeling in hypertension. Low miR-1929-3p expression induced by murine cytomegalovirus (MCMV) infection is closely related to hypertensive myocardial re...
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Article
Mid-term efficacy grading evaluation and predictive factors of magnetic resonance–guided focused ultrasound surgery for painful bone metastases: a multi-center study
MR imaging–guided focused ultrasound surgery (MRgFUS) is an emerging non-invasive treatment. It
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Chapter and Conference Paper
Research on Reliability of Beidou Short Message Based on Turbo Code
Beidou short message is the priority among priorities of independent research and development of Beidou navigation system in China. It has a wide range of application, wide range of use, low investment cost an...
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Chapter and Conference Paper
TRindex: Distributed Double-Layer Road Network Trajectory Index
With the wide application of mobile device positioning technology, the scale of traffic trajectory data generated is becoming larger and larger. How to store this massive data is a hot research topic in recent...
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Article
Open AccessTRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca2+ leakage
Intracellular Ca2+ dysregulation is a key marker in septic cardiac dysfunction; however, regulation of the classic Ca2+ regulatory modules cannot successfully abolish this symptom. Here we show that the knockout ...
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Article
Retraction Note: Oral Bioavailability Improvement of Tailored Rosuvastatin Loaded Niosomal Nanocarriers to Manage Ischemic Heart Disease: Optimization, Ex Vivo and In Vivo Studies
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Article
Functional trait-based potential invasiveness of exotic submerged macrophytes and their effects on sediment bacterial community
Functional traits of exotic species play an important role in their invasive process by enhancing their performance and promoting them as a potentially malignant invasive species. However, the interrelationshi...
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Article
Production of p-rich nuclei with \(\boldsymbol{Z}\boldsymbol{=20-25}\) based on radioactive ion beams
Within the framework of isospin-dependent Boltzmann-Langevin model, the production cross sections of proton-rich nuclei with \(Z = 20-25\) ...
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Article
Identification of antimicrobial peptides from the human gut microbiome using deep learning
The human gut microbiome encodes a large variety of antimicrobial peptides (AMPs), but the short lengths of AMPs pose a challenge for computational prediction. Here we combined multiple natural language proces...
