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Article
Open AccessCardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction
The activation of G protein-coupled receptors (GPCR) signaling by external stimuli has been implicated in inducing cardiac stress and stress responses. GPR22 is an orphan GPCR expressed in brains and hearts, w...
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Article
Fostering students’ scientific literacy by reflective questioning: An identification, summarization, self-reflective questioning, and application (ISSA)-based flipped learning approach
Develo** students’ scientific literacy is the most important educational goal and challenge of the 21st century. Many studies have confirmed that flipped learning has significantly impacted learning science....
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Article
VR-assisted inquiry-based learning to promote students’ science learning achievements, sense of presence, and global perspectives
Due to globalization, emerging technologies, and the knowledge economy, there has been a growing emphasis on students having global competencies and perspectives to succeed in an increasingly interconnected wo...
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Article
Assessing Taiwan’s pay-for-performance program for diabetes care: a cost–benefit net value approach
Pay-for-Performance (P4P) to better manage chronic conditions has yielded mixed results. A better understanding of the cost and benefit of P4P is needed to improve program assessment. To this end, we assessed ...
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Article
A concept map**-based prediction-observation-explanation approach to promoting students’ flipped learning achievements and perceptions
Previous research has illustrated the potential of flipped learning for assisting teachers in designing meaningful activities to promote students’ higher order thinking skills; however, several previous studie...
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Open AccessDose-dependent benefits of iron-magnetic nanoparticle-coated human umbilical-derived mesenchymal stem cell treatment in rat intracranial hemorrhage model
This study tested whether two doses of human umbilical-derived mesenchymal stem cells (hUC-MSCs) were superior to one dose for protecting the brain against intracranial hemorrhage (ICH) induced by intracranial...
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Article
Open AccessA Real-World Analysis of Patients with Untreated Metastatic Epidermal Growth Factor Receptor (EGFR)-Mutated Lung Adenocarcinoma Receiving First-Line Erlotinib and Bevacizumab Combination Therapy
The clinical features of patients with metastatic epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma receiving first-line therapy based on erlotinib combined with bevacizumab are unclear. Here...
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Article
Open AccessAdditional benefit of induced pluripotent stem cell-derived mesenchymal stem cell therapy on sepsis syndrome-associated acute kidney injury in rat treated with antibiotic
This study tested whether human induced-pluripotent stem-cell-derived mesenchymal-stem-cells (iPS-MSCs) would offer an additional benefit to the rodent with acute kidney injury (AKI) (ischemia for 1 h followed...
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Article
Impacts of augmented reality and a digital game on students’ science learning with reflection prompts in multimedia learning
Although a great deal of research has evidenced the effects of proper instructional design on multimedia learning, most has focused on the cognitive aspects of learning, with little concern about the role of a...
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Article
Are quality-adjusted medical prices declining for chronic disease? Evidence from diabetes care in four health systems
Improvements in medical treatment have contributed to rising health spending. Yet there is relatively little evidence on whether the spending increase is “worth it” in the sense of producing better health outc...
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Article
Open AccessEffects of a quasi-experimental study of using flipped classroom approach to teach evidence-based medicine to medical technology students
Flipped classroom is known to improve learning efficiency and to develop one’s ability to apply high-level knowledge. To investigate the effect of flipped classroom approach on teaching evidence-based medicine...
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Article
Open AccessA community-based study on the association between Helicobacter pylori Infection and obesity
Helicobacter pylori (H. pylori) infection can induce chronic inflammation and is associated with insulin resistance, metabolic syndrome and body mass index (BMI, kg/m2) changes. This study aimed to evaluate the a...
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Article
Instability in dynamic fracture and the failure of the classical theory of cracks
Understanding crack formation is important for improving the mechanical performance of materials. A new theory is now presented for the description of cracks propagating at high speeds, with elastic nonlineari...
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Article
Residual stress analysis and bow simulation of crystalline silicon solar cells
The pressure to reduce solar energy costs encourages efforts to reduce the thickness of silicon wafers. Thus, the cell bowing problem associated with the use of thin wafers has become increasingly important, a...
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Article
Open AccessValidity of a stroke severity index for administrative claims data research: a retrospective cohort study
Ascertaining stroke severity in claims data-based studies is difficult because clinical information is unavailable. We assessed the predictive validity of a claims-based stroke severity index (SSI) and determi...
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Evaluation of Adaptation Strategies for Urban Flooding in Central Taipei City in Taiwan
The urban areas have been rapidly developed in Taiwan in recent years. The expanding urban areas and the increasing population, especially in the metropolitan Taipei city, result in surface runoff discharge du...
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Article
Mortality, disability, and intensive care in patients with mitochondrial 3243A>G mutation
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Article
Sitagliptin protects rat kidneys from acute ischemia-reperfusion injury via upregulation of GLP-1 and GLP-1 receptors
Sitagliptin, an oral glucose-lowering agent, has been found to produce cardiovascular protection possibly via anti-inflammatory and anti-atherosclerotic activities of glucagon-like peptide-1 receptor (GLP-1). ...
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Article
Open AccessLevels and values of lipoprotein-associated phospholipase A2, galectin-3, RhoA/ROCK, and endothelial progenitor cells in critical limb ischemia: pharmaco-therapeutic role of cilostazol and clopidogrel combination therapy
We tested the hypothesis that clopidogrel and cilostazol combination therapy could effectively attenuate systemic inflammatory reaction, facilitate proliferation of circulating endothelial progenitor cell (EPC...
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Article
Open AccessOxfordshire community stroke project classification improves prediction of post-thrombolysis symptomatic intracerebral hemorrhage
The Oxfordshire Community Stroke Project (OCSP) classification is a simple stroke classification system with value in predicting clinical outcomes. We investigated whether and how the addition of OCSP classifi...
