22 Result(s)

Article

Rejuvenated endothelial progenitor cells through overexpression of cellular prion protein effectively salvaged the critical limb ischemia in rats with preexisting chronic kidney disease

This study tested the hypothesis that overexpression of cellular prion protein in endothelial progenitor cells (PrPc^OE-EPCs), defined as “rejuvenated EPCs,” was superior to EPCs for salvaging the critical limb is...

Jui-Po Yeh, Pei‐Hsun Sung, John Y. Chiang, Chi-Ruei Huang… in Stem Cell Research & Therapy (2022)

Article

Dose-dependent benefits of iron-magnetic nanoparticle-coated human umbilical-derived mesenchymal stem cell treatment in rat intracranial hemorrhage model

This study tested whether two doses of human umbilical-derived mesenchymal stem cells (hUC-MSCs) were superior to one dose for protecting the brain against intracranial hemorrhage (ICH) induced by intracranial...

Kuan-Hung Chen, Han-Tan Chai, Kun-Chen Lin, John Y. Chiang… in Stem Cell Research & Therapy (2022)

Article

Intrarenal arterial administration of human umbilical cord-derived mesenchymal stem cells effectively preserved the residual renal function of diabetic kidney disease in rat

This experimental study was designed as a preclinical study for testing the hypothesis that intrarenal arterial (IRA) transfusion of human umbilical cord-derived mesenchymal stem cells (HUCDMSCs) therapy prese...

Ya Yue, Jui-Ning Yeh, John Y. Chiang, Pei-Hsun Sung… in Stem Cell Research & Therapy (2022)

Article

Additional benefit of induced pluripotent stem cell-derived mesenchymal stem cell therapy on sepsis syndrome-associated acute kidney injury in rat treated with antibiotic

This study tested whether human induced-pluripotent stem-cell-derived mesenchymal-stem-cells (iPS-MSCs) would offer an additional benefit to the rodent with acute kidney injury (AKI) (ischemia for 1 h followed...

Chih-Chao Yang, Pei‐Hsun Sung, Chih-Hung Chen… in Stem Cell Research & Therapy (2021)

Article

Combined melatonin-adipose derived mesenchymal stem cells therapy effectively protected the testis from testicular torsion-induced ischemia-reperfusion injury

This study tested the hypothesis that combined melatonin (Mel) and adipose-derived mesenchymal stem cells (ADMSCs) treatment was superior to either one alone on protecting the testis against acute testicular t...

Yen-Ta Chen, Fei-Chi Chuang, Chih-Chao Yang, John Y. Chiang… in Stem Cell Research & Therapy (2021)

Article

Double overexpression of miR-19a and miR-20a in induced pluripotent stem cell-derived mesenchymal stem cells effectively preserves the left ventricular function in dilated cardiomyopathic rat

This study tested the hypothesis that double overexpression of miR-19a and miR-20a (dOex-mIRs) in human induced pluripotent stem cell (iPS)-derived mesenchymal stem cells (MSCs) effectively preserved left vent...

Jiunn-Jye Sheu, Han-Tan Chai, Pei-Hsun Sung, John Y. Chiang… in Stem Cell Research & Therapy (2021)

Article

Dipeptidyl peptidase 4 promotes peritoneal fibrosis and its inhibitions prevent failure of peritoneal dialysis

Peritoneal dialysis (PD) possesses multiple advantages for end stage renal disease. However, long-term PD triggers peritoneal fibrosis (PF). From the nationwide analysis of diabetic PD patients (n = 19,828), we i...

Yi-Chen Li, Pei-Hsun Sung, Yao-Hsu Yang, John Y. Chiang… in Communications Biology (2021)

Article

Baseline factors identified for the prediction of good responders in patients with end-stage diffuse coronary artery disease undergoing intracoronary CD34+ cell therapy

Treating patients with end-stage diffuse coronary artery disease (EnD-CAD) unsuitable for coronary intervention remains a clinical challenge. They usually express refractory angina and have a high risk of mort...

Pei-Hsun Sung, Hsin-Ju Chiang, Yi-Chen Li, John Y. Chiang… in Stem Cell Research & Therapy (2020)

Article

Intra-carotid arterial transfusion of circulatory-derived autologous endothelial progenitor cells in rodent after ischemic stroke—evaluating the impact of therapeutic time points on prognostic outcomes

This study tested the optimal time point for left intra-carotid arterial (LICA) administration of circulatory-derived autologous endothelial progenitor cells (EPCs) for improving the outcome in rat after acute...

Kun-Chen Lin, Han-Tan Chai, Kuan-Hung Chen, Pei-Hsun Sung… in Stem Cell Research & Therapy (2020)

Article

Administration of antioxidant peptide SS-31 attenuates transverse aortic constriction-induced pulmonary arterial hypertension in mice

Antioxidant peptide SS-31 is a class of cell-permeable small peptides, which selectively resides on the inner mitochondrial membrane and possesses intrinsic mitochondrial protective capacities. In this study w...

Hung-i Lu, Tien-hung Huang, Pei-hsun Sung, Yung-lung Chen… in Acta Pharmacologica Sinica (2016)

Article

Erratum to: Erythropoietin improves long-term neurological outcome in acute ischemic stroke patients: a randomized, prospective, placebo-controlled clinical trial

Tzu-Hsien Tsai, Cheng-Hsien Lu, Christopher Glenn Wallace, Wen-Neng Chang… in Critical Care (2016)

Article

Erythropoietin improves long-term neurological outcome in acute ischemic stroke patients: a randomized, prospective, placebo-controlled clinical trial

Mortality and disability following ischemic stroke (IS) remains unacceptably high with respect to the conventional therapies. This study tested the effect of erythropoietin (EPO) on long-term neurological outc...

Tzu-Hsien Tsai, Cheng-Hsien Lu, Christopher Glenn Wallace, Wen-Neng Chang… in Critical Care (2015)

Article

The impact of previous ovarian surgery on ovarian reserve in patients with endometriosis

To investigate the impact of previous ovarian surgery on ovarian reserve in patients with endometriosis.

Hsin-Ju Chiang, Pin-Yao Lin, Fu-Jen Huang, Fu-Tsai Kung, Yu-Ju Lin… in BMC Women's Health (2015)

Article

Sitagliptin protects rat kidneys from acute ischemia-reperfusion injury via upregulation of GLP-1 and GLP-1 receptors

Sitagliptin, an oral glucose-lowering agent, has been found to produce cardiovascular protection possibly via anti-inflammatory and anti-atherosclerotic activities of glucagon-like peptide-1 receptor (GLP-1). ...

Meng-wei Chang, Chih-hung Chen, Yi-ching Chen, Ying-chun Wu… in Acta Pharmacologica Sinica (2015)

Article

Levels and values of lipoprotein-associated phospholipase A₂, galectin-3, RhoA/ROCK, and endothelial progenitor cells in critical limb ischemia: pharmaco-therapeutic role of cilostazol and clopidogrel combination therapy

We tested the hypothesis that clopidogrel and cilostazol combination therapy could effectively attenuate systemic inflammatory reaction, facilitate proliferation of circulating endothelial progenitor cell (EPC...

Jiunn-Jye Sheu, Pao-Yuan Lin, Pei-Hsun Sung… in Journal of Translational Medicine (2014)

Article

Apoptotic adipose-derived mesenchymal stem cell therapy protects against lung and kidney injury in sepsis syndrome caused by cecal ligation puncture in rats

We tested the hypothesis that apoptotic adipose-derived mesenchymal stem cells (A-ADMSC) are superior to healthy (H)-ADMSC in attenuating cecal ligation puncture (CLP)-induced sepsis-mediated lung and kidney i...

Pei-Hsun Sung, Chia-Lo Chang, Tzu-Hsien Tsai, Li-Teh Chang… in Stem Cell Research & Therapy (2013)