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  1. Article

    Open Access

    Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction

    The activation of G protein-coupled receptors (GPCR) signaling by external stimuli has been implicated in inducing cardiac stress and stress responses. GPR22 is an orphan GPCR expressed in brains and hearts, w...

    Chin-Chuan Chang, Chih-Hung Chen, Shu-Yuan Hsu, Steve Leu in BMC Cardiovascular Disorders (2024)

  2. Article

    Open Access

    Iterated cross validation method for prediction of survival in diffuse large B-cell lymphoma for small size dataset

    Efforts have been made to improve the risk stratification model for patients with diffuse large B-cell lymphoma (DLBCL). This study aimed to evaluate the disease prognosis using machine learning models with it...

    Chin-Chuan Chang, Chien-Hua Chen, Jer-Guang Hsieh, Jyh-Horng Jeng in Scientific Reports (2023)

  3. No Access

    Chapter

    Biocompatibility of Materials for Biomedical Engineering

    In the tissue engineering research field, nanobiomaterials highlight the impact of novel bioactive materials in both current applications and their potentials in future progress for tissue engineering and rege...

    Yu-Chang Tyan, Ming-Hui Yang, Chin-Chuan Chang, Tze-Wen Chung in Biomimicked Biomaterials (2020)

  4. Article

    Open Access

    Prognostic Significance of Metabolic Parameters and Textural Features on 18F-FDG PET/CT in Invasive Ductal Carcinoma of Breast

    To investigate the prognostic significance of metabolic parameters and texture analysis on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in patients with breast invasive duc...

    Chin-Chuan Chang, Chao-Jung Chen, Wen-Ling Hsu, Shu-Min Chang in Scientific Reports (2019)

  5. No Access

    Article

    Towards metabolic sink therapy for mut methylmalonic acidaemia: Retrovirus-mediated transfer of the human methylmalonyl-CoA mutase cDNA into peripheral blood progenitor cells of a child with mut methylmalonic acidaemia

    Chin-Chuan Chang, Kwang-Jen Hsiao, Mao-Liang Chen in Journal of Inherited Metabolic Disease (1999)

  6. No Access

    Chapter

    Assessment of Toxicity and Antifertility Efficacy of Gossypol in Male Rats

    The discovery by Chinese scientists of gossypol as an anti- fertility agent for men aroused a great deal of interest around the world in assessing its fertility regulating action in a variety of laboratory ani...

    Chin-Chuan Chang, Sheldon J. Segal in Gossypol (1985)

  7. No Access

    Chapter

    Gossypol Studies in Male Rats

    Gossypol, a yellow phenolic pigment of the cotton plant [1], has occupied the attention of agricultural research groups for many years because of its toxicity to monogastric animals. The usual manifestations o...

    Chin-Chuan Chang, Zhi** Gu, Yun-Yen Tsong in Gossypol (1985)