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Article
Open AccessTemporal-spatial deciphering mental subtraction in the human brain
Mental subtraction, involving numerical processing and operation, requires a complex interplay among several brain regions. Diverse studies have utilized scalp electroencephalograph, electrocorticogram, or fun...
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Article
Open AccessUnraveling the genetic architecture of congenital vertebral malformation with reference to the develo** spine
Congenital vertebral malformation, affecting 0.13–0.50 per 1000 live births, has an immense locus heterogeneity and complex genetic architecture. In this study, we analyze exome/genome sequencing data from 873...
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Article
Zebrafish: an important model for understanding scoliosis
Scoliosis is a common spinal deformity that considerably affects the physical and psychological health of patients. Studies have shown that genetic factors play an important role in scoliosis. However, its eti...
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Article
Biodiversity-based development and evolution: the emerging research systems in model and non-model organisms
Evolutionary developmental biology, or Evo-Devo for short, has become an established field that, broadly speaking, seeks to understand how changes in development drive major transitions and innovation in organ...
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Article
Melatonin Reverses 10-Hydroxycamptothecin-Induced Apoptosis and Autophagy in Mouse Oocyte
10-Hydroxycamptothecin (HCPT) is a widely used anticancer drug that induces cytotoxicity by triggering the cell apoptotic pathway. Studies have shown that HCPT has harmful effects on normal cells, but whether ...
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Article
Open AccessPrimary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish
Hematopoietic stem and progenitor cells (HSPCs) are capable of producing all mature blood lineages, as well as maintaining the self-renewal ability throughout life. The hairy-like organelle, cilium, is present...
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Article
Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis
Straightening of the body axis is a major morphogenetic event that produces the typical head-to-tail shape of the vertebrate embryo. Defects in axial straightening can lead to debilitating disorders such as id...
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Article
Open AccessScallop genome provides insights into evolution of bilaterian karyotype and development
Reconstructing the genomes of bilaterian ancestors is central to our understanding of animal evolution, where knowledge from ancient and/or slow-evolving bilaterian lineages is critical. Here we report a high-...
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Article
elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8
The formation and function of cilia involves the movement of intraflagellar transport (IFT) particles underneath the ciliary membrane, along axonemal microtubules1,2. Although this process has been studied extens...
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Article
Somite-specific expression of a novel fibronectin variant FN3 is negatively regulated by SHH
Fibronectins (FNs) are major extracellular proteins in blood plasma and many tissues of vertebrates, and play important roles in adhesion, migration and differentiation of cells. We have identified a novel var...
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Article
Zebrafish sox9b is an early neural crest marker
Sox9 is a transcription factor related to campomelic dysplasia and sex reversal in human patients. Earlier studies in zebrafish led to the identification of two homologues of mammalian sox9, sox9a and sox9b. The...
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Article
The zygotic expression of zebrafish trebf during embryogenesis is restricted to the embryonic shield and its derivatives
We have identified a zebrafish gene trebf that shows an overall similarity of 51.5% and 55.1% in amino acid sequence with human and mouse TREB5/hXBP-1/HTF, respectively. Northern hybridization reveals that trebf
