14 Result(s)
within
Saikat Mukhopadhyay
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Article
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway
The orphan G protein-coupled receptor (GPCR) GPR161 plays a central role in development by suppressing Hedgehog signaling. The fundamental basis of how GPR161 is activated remains unclear. Here, we determined ...
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Article
Translational regulation of δ-tubulin through its 5’-untranslated region
δ-tubulin - a member of tubulin superfamily, is found in a subset of eukaryotes including human where it has a role in centriole maturation. The mutation in the gene results in a disorganized microtubule tripl...
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Article
Open AccessHuman IFT-A complex structures provide molecular insights into ciliary transport
Intraflagellar transport (IFT) complexes, IFT-A and IFT-B, form bidirectional trains that move along the axonemal microtubules and are essential for assembling and maintaining cilia. Mutations in IFT subunits ...
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Protocol
Studying Hedgehog Signaling During Mouse Neural Tube Development
The identity of ventral neural progenitors in the neural tube is largely dependent on Hedgehog (Hh) signaling. Variations in staining patterns are excellent indicators of aberrant Hh signaling. Here we describ...
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Article
Open AccessInterface controlled thermal resistances of ultra-thin chalcogenide-based phase change memory devices
Phase change memory (PCM) is a rapidly growing technology that not only offers advancements in storage-class memories but also enables in-memory data processing to overcome the von Neumann bottleneck. In PCMs,...
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Article
Cellular signalling by primary cilia in development, organ function and disease
Primary cilia project in a single copy from the surface of most vertebrate cell types; they detect and transmit extracellular cues to regulate diverse cellular processes during development and to maintain tiss...
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Article
Open AccessOptic phonons and anisotropic thermal conductivity in hexagonal Ge2Sb2Te5
The lattice thermal conductivity (κ) of hexagonal Ge2Sb2Te5 (h-GST) is studied via direct first-principles calculations. We find significant intrinsic anisotropy (κa/κc~2) of κ in bulk h-GST, with the dominant co...
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Article
Open AccessCompeting covalent and ionic bonding in Ge-Sb-Te phase change materials
Ge2Sb2Te5 and related phase change materials are highly unusual in that they can be readily transformed between amorphous and crystalline states using very fast melt, quench, anneal cycles, although the resulting...
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Article
Twisting phonons in complex crystals with quasi-one-dimensional substructures
A variety of crystals contain quasi-one-dimensional substructures, which yield distinctive electronic, spintronic, optical and thermoelectric properties. There is a lack of understanding of the lattice dynamic...
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Article
Microscopic insight into molecular orbital gating
The molecular orbital gating in the 1,8-octanedithiol (ODT) and 1,4-benzenedithiol (BDT) molecules is investigated using first principles methods. The calculated I–V characteristics as a function of applied gate ...
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Article
Open AccessCilia, tubby mice, and obesity
Primary cilia have been previously linked to the central regulation of satiety. Thetubby mouse is characterized by maturity-onset obesity and blindness. Arecent paper demonstrates molecular defects in trafficking...
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Article
Mechanism(s) of Alteration of Micro RNA Expressions in Huntington’s Disease and Their Possible Contributions to the Observed Cellular and Molecular Dysfunctions in the Disease
To identify the mechanism of deregulation of micro RNAs (miRNAs) altered in Huntington’s disease (HD) and their possible contributions to the altered cellular and molecular functions observed in the disease, w...
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Article
The tubby family proteins
The tubby mouse shows a tripartite syndrome characterized by maturity-onset obesity, blindness and deafness. The causative gene Tub is the founding member of a family of related proteins present throughout the an...
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Article
elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8
The formation and function of cilia involves the movement of intraflagellar transport (IFT) particles underneath the ciliary membrane, along axonemal microtubules1,2. Although this process has been studied extens...
